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Table 3 BPA effects on the uterus in animal experiments

From: Bisphenol a and the female reproductive tract: an overview of recent laboratory evidence and epidemiological studies

Study Sample Dose Route of administration Time of exposure Results
Mendoza-Rodriguez et al. [48] Female rat offspring 1.2 mg/kg BW/day BPA diluted in drinking water GD 6- D 21 of lactation BPA offspring: irregular estrous cycles; significant increase in the thickness of uterine epithelium and stroma; modifications in apoptotic patterns of uterine epithelium and ERα downregulation
Newbold et al. [49] Mice 0.1 (BPA 0.1), 1 (BPA 1), 10 (BPA10), 100 (BPA 100), 1000 (BPA 1000) μg/kg/day Subcutaneous injections GD 9-16 Adenomatous hyperplasia in BPA1 and BPA100 not in controls; atypical hyperplasia in BPA 0.1, BPA 1, BPA 1000 not in controls; endometrial polyps in BPA 0.1, BPA 1, BPA 10; stromal sarcoma in one BPA 100 mouse
Varayoud et al. [53] Female rats 0.05 (BPA 0.5), 20 (BPA 20) mg/kg day Subcutaneous injections PND 1,3,5,7 Pregnancies were not established in 10% of BPA 0.5 and in 23% of BPA 20, whereas in the controls the pregnancy rate was 100%; decreased number of implantation sites in BPA20; lower ERα and PR expression; lower expression of Hoxa10
Bromer et al. [54] Female mouse offspring 5 mg/kg Intraperitoneal injections GD 9-16 Hoxa10 increased expression; decreased DNA methylation in the promoter and in intron regions of Hoxa10 with consequent increase in binding of ER-α to Hoxa10 ERE
Xiao et al. [55] Pregnant mice 0, 0.025, 0.5, 10, 40, 100 mg/kg/day Subcutaneous injections GD 0.5-3.5 No implantation sites in BPA 100 treated group; smaller implantation sites, increased gestation period, reduced postnatal survival rate in 40 BPA treated group; alterations in PR expression.