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Table 3 Summary of studies with longitudinal follow-up of serum AMH levels in young girls undergoing chemotherapy (CT) for childhood cancer

From: Serum AMH level as a marker of acute and long-term effects of chemotherapy on the ovarian follicular content: a systematic review

Study Cancer Treatment Age (range) Times of AMH measurement Number of patients Conclusions about AMH follow up
Broughman, 2012 [54] Different type of cancer Different protocols (low/ medium/high gonadotoxic protocols) 4,4 (0,3-15) Before CT, after each CT course, between 2 and 12 months post CT, >12 months post CT 22 (9 high gonadotoxic protocol, 13 medium or low gonadotoxic protocol) No difference between protocols regarding the depletion phase:
-Significant fall of AMH levels from the third cycle of CT in all protocols.
-Undetectable values of AMH in most patients at the end of CT.
Different recovery phases according to protocol:
-Very low or undetectable AMH levels in the high gonadotoxic group more than 12 months post CT.
       -Return to pre-treatment AMH values as soon as the 6th month of follow-up in the medium/low group risk.
Mörse, 2013 [55] Different type of cancer Different protocols 9,5 (4,5-16,5) Before CT, Every 3 month during and after CT 34 (27 alkylating protocol) No difference between protocols regarding the depletion phase:
-Significant fall of AMH levels 3 months after initiation of CT.
Different recovery phases according to protocol:
-Very low or undetectable AMH levels in the group with irradiation below the diaphragm and/or stem cell transplantation 18 month post follow-up.
       -Return to pre-treatment or higher AMH values as soon as the 15th month of follow-up in acute lymphatic leukemia group.