|
Broughman, 2012 [54]
|
Different type of cancer
|
Different protocols (low/ medium/high gonadotoxic protocols)
|
4,4 (0,3-15)
|
Before CT, after each CT course, between 2 and 12 months post CT, >12 months post CT
|
22 (9 high gonadotoxic protocol, 13 medium or low gonadotoxic protocol)
|
No difference between protocols regarding the depletion phase:
|
|
-Significant fall of AMH levels from the third cycle of CT in all protocols.
|
|
-Undetectable values of AMH in most patients at the end of CT.
|
|
Different recovery phases according to protocol:
|
|
-Very low or undetectable AMH levels in the high gonadotoxic group more than 12 months post CT.
|
| | | | | | |
-Return to pre-treatment AMH values as soon as the 6th month of follow-up in the medium/low group risk.
|
|
Mörse, 2013 [55]
|
Different type of cancer
|
Different protocols
|
9,5 (4,5-16,5)
|
Before CT, Every 3 month during and after CT
|
34 (27 alkylating protocol)
|
No difference between protocols regarding the depletion phase:
|
|
-Significant fall of AMH levels 3 months after initiation of CT.
|
|
Different recovery phases according to protocol:
|
|
-Very low or undetectable AMH levels in the group with irradiation below the diaphragm and/or stem cell transplantation 18 month post follow-up.
|
| | | | | | |
-Return to pre-treatment or higher AMH values as soon as the 15th month of follow-up in acute lymphatic leukemia group.
|
