Skip to main content

Advertisement

Table 2 Results of meta-regression for the effect of subgroup and covariates analyses for number of oocytes and clinical pregnancy

From: Recombinant human follicle-stimulating hormone (r-hFSH) plus recombinant luteinizing hormone versus r-hFSH alone for ovarian stimulation during assisted reproductive technology: systematic review and meta-analysis

Moderator (covariate)a Number of oocytes Clinical pregnancy
  Difference 95% CI Pvalue RR 95% CI P value
Analysis of patient response subgroups       
POR vs. normal responders 1.17 0.42 to 1.92 0.002 1.3 1.05 to 1.62 0.016
Other analyses       
Advanced maternal age (>35 years) vs. younger age −0.66 −1.51 to 0.20 0.132 1.1 0.90 to 1.33 0.378
Typology (NPG class vs. othersb) 1.40 0.35 to 2.46 0.009 1.3 0.98 to 1.75 0.067
Missing data: imputed vs existing data 1.52 −3.68 to 6.73 0.566 1.3 0.76 to 2.23 0.332
Publication year −0.04 −0.16 to 0.09 0.577 1.0 0.97 to 1.03 0.934
Published vs. unpublished (congress abstracts) 0.87 −0.76 to 2.51 0.296 0.7 0.44 to 1.25 0.262
Published vs. unpublished (full papers) 0.27 −1.22 to 1.75 0.724 0.8 0.48 to 1.30 0.346
Methodological quality score (MQS) −0.96 −2.44 to 0.52 0.204 0.9 0.68 to 1.30 0.693
Sponsored vs. non-sponsored studies −0.35 −1.15 to 0.45 0.394 0.9 0.78 to 1.09 0.346
Multicentre vs. single centre 0.36 −0.45 to 1.17 0.386 0.9 0.80 to 1.12 0.517
ART technique (ICSI vs. IVF) 0.21 −0.17 to 0.59 0.281 1.1 0.94 to 1.33 0.212
GnRH antagonist vs. GnRH agonist −0.12 −1.02 to 0.77 0.787 0.9 0.78 to 1.10 0.364
  1. aWith the exception of continuous variables, the categories of the meta-regressors were binary, e.g. POR vs. normal responders.
  2. bOther typology groups: NNG (young/normal age, normal response, GnRH agonist); ANG (advanced maternal age, normal response, GnRH agonist); NNN (young/normal age, normal response, GnRH antagonist); NPN (young/normal age, poor response, GnRH antagonist); APG (advanced maternal age, poor response, GnRH agonist); and ANN (advanced maternal age, normal response, GnRH antagonist).
  3. ART, assisted reproductive technology; CI, confidence interval; GnRH, gonadotrophin-releasing hormone; ICSI, intracytoplasmic sperm injection; IVF, in vitro fertilization; NPG, young/normal age, poor response, GnRH agonist; POR, poor ovarian response; RR, risk ratio.