In high responding patients undergoing an initial IVF cycle, elevated estradiol on the day of hCG has no effect on live birth rate

Table 2 Estradiol groups in the entire population of patients and IVF outcome

Variables	Group 1 < 2000 pg/mL, n = 123)	Group 2 (2000-4000) pg/ml, n = 288)	Group 3 > 4000 pg/mL, n = 78)	p- value
Age (years)	32.6 ± 4.2	31.5 ± 4.1	30.6 ± 3.8	<0.003
BMI	27.4 ± 7.0	26.3 ± 6.2	24.9 ± 6.1	<0.024
FSH dose (IU)*	3851 ± 1454	2883 ± 1314	1900 ± 896	<0.001
Peak estradiol (pg/mL)	1489 ± 365	2950.1 ± 561	4758 ± 594	<0.001
Oocytes retrieved	11.9 ± 5.7	19.9 ± 7.5	26.5 ± 8.6	<0.001
MII oocytes	8.9 ± 4.7	15.1 ± 6.3	20.7 ± 7.3	<0.001
Total 2PN	6.4 ± 3.7	10.3 ± 4.7	13.5 ± 5.9	<0.001
AEQS	1.78 ± 0.67	1.57 ± 0.58	1.48 ± 0.44	<0.001
No. embryos transferred	2.11 ± 0.50	2.04 ± 0.40	1.92 ± 0.35	<0.008
BCP (%)	58.5^a	70.8^b	78.2^b	<0.007
CP (%)	49.6^a	64.2^b	65.4^b	<0.015
LB (%)	47.2	59.0	61.5	0.052
Total pregnancy loss (%)	19.4	16.7	21.3	0.670
Poor quality embryos for transfer (%)	19.5	9.7	1.3	<0.001

Mean ± 1SD.
Chi-square and ANOVA tests as appropriate. For pregnancy related variables, within row, response variables with different superscripts differ at a minimum of P < 0.05. The number patients in the entire population were 489. *The n for FSH dose was 470 due to missing values.

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