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Table 1 Toxic compounds tested in vitro using bovine and porcine models

From: Usefulness of bovine and porcine IVM/IVF models for reproductive toxicology

Environmental Species Exposure Cumulus Oocytes Embryos
  Bovine Porcine IVM IVF IVC Viability Expansion Viability MII Fertilization/Activation 2-4 cells Blast N nuclei Ploidy
Anabasine [86]   86 86     86        
Atrazine [17, 87, 88] 17,87 88 17,87,88 87   17,88    17, 88 87   87   
Benzo(a)pyrene [15] 15   15 15   15    15 15     
Benzyl butyl phthalate [89]   89 89     89   89      
Cadmium [15, 17, 86] 15,17 86 15,17,86 15   15,17 86   15,17 15     
Carbedazim [15] 15   15 15   15    15 15     
4-Chloro-3-methyl phenol [89]   89 89     89   89      
Cotinine [17, 86] 17 86 17,86    17 86   17      
Cycloheximide [15, 17] 15,17   15,17 15   15,17    15,17 15     
DEHP [89, 90] 90 89 89,90     89   89,90   90 90   
Diazinon [88, 91]   88,91 88,91 91 91 88   91 88 91 91 91   
DDT [92] 92   92       92 92 92 92 92  
Fenoxaprop-ethyl [88]   88 88    88    88      
Hexachlorocyclohexane [92] 92   92       92 92 92 92 92  
Lindane [15] 15   15 15   15    15 15     
Malathion [88, 91]   88,91 88,91 91 91 88   91 88 91 91 91   
Methoxychlor [92] 92   92       92 92 92 92 92  
MEHP [17, 90, 93] 17,90,93   17,90,93    17 93   17,90,93   90 90   
Nanoparticles Au-Ag [94]   94 94     94   94      
Nicotine [17, 86, 95, 96] 17,95,96 86 17,86,95,96 95 95 17 86,95   17,95,96 95 95,96 95,96 96 96
PCB mixtures [19, 97–102] 97-99 19,100-102 19,97-101 101 102 19,99,100 19,100 19 19,97-100 19,97,98, 100,101 19,97, 98,101 19,97,98, 100-102 98,101, 102  
4-tert-octylphenol [103] 103   103       103 103 103 103 103  
Food               
Bisphenol A [89]   89 89     89   89      
α-Chaconine [104] 104   104 104 104       104 104   
Daidzein [105]   105 105     105   105 105 105 105   
Deoxynivalenol [106–108]   106-108 106-108   106 108 108   106-108 108 107,108 107,108 107,108 107,108
Flavanones [109]   109 109     109   109 109 109 109   
Genistein [15] 15   15 15   15    15 15     
α-Solanine [104] 104   104 104 104       104 104   
Solanidine-N-oxide [104] 104   104 104 104       104 104   
Zearelanone [107, 110, 111] 110,111 107 107,110,111       107,110, 111   107,110 107,110 107 107
α-zearalenol [106, 107, 112]   106,107, 112 106,107   106     106, 107   107,112 107,112 107,112 107
β-zearalenol [106, 107]   106,107        106,107   107 107 107 107
Drugs               
Busulfan [15] 15   15 15   15    15 15     
Diethylstilbestro l [15, 17] 15,17   15,17 15   15,17    15,17 15     
17β-Estradiol [17, 103] 17,103   17,103    17    17,103 103 103 103 103  
Ionomycin [15] 15   15 15   15    15 15     
Ketoconazole [15] 15   15 15   15    15 15     
Methyl acetoacetate [15] 15   15 15   15    15 15     
Mifepristone [15] 15   15 15   15    15 15     
Nocodazole [15, 17] 15,17   15,17 15   15,17    15,17 15     
Okadaic acid [95] 95   95     95   95      
Piperazine [17] 17   17    17    17      
Swainsonine [113] 113   113 113 113       113 113 113  
Taxol [95] 95   95     95   95      
Cosmetics               
Butylparaben [15] 15   15 15   15    15 15     
9-cis-Retinoic acid [114] 114   114         114 114   
Retinoic acid [17] 17   17    17    17      
Occupational               
Acrylamide [17] 17   17    17    17      
  1. DDT: Dichlorodiphenyltrichloroethane; DEHP: Di-(2-ethylhexyl) phthalate; MEHP: Mono-(2-ethylhexyl) phthalate; PCB: polychlorinated biphenyl.
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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