Usefulness of bovine and porcine IVM/IVF models for reproductive toxicology

Santos, Regiane R; Schoevers, Eric J; Roelen, Bernard AJ

doi:10.1186/1477-7827-12-117

Reproductive Biology and Endocrinology

Table 1 Toxic compounds tested in vitro using bovine and porcine models

From: Usefulness of bovine and porcine IVM/IVF models for reproductive toxicology

*Environmental*	Species		Exposure			*Cumulus*		Oocytes			Embryos
	Bovine	Porcine	IVM	IVF	IVC	Viability	Expansion	Viability	MII	Fertilization/Activation	2-4 cells	Blast	N nuclei	Ploidy
Anabasine [86]		86	86				86
Atrazine [17, 87, 88]	17,87	88	17,87,88	87		17,88			17, 88	87		87
Benzo(a)pyrene [15]	15		15	15		15			15	15
Benzyl butyl phthalate [89]		89	89				89		89
Cadmium [15, 17, 86]	15,17	86	15,17,86	15		15,17	86		15,17	15
Carbedazim [15]	15		15	15		15			15	15
4-Chloro-3-methyl phenol [89]		89	89				89		89
Cotinine [17, 86]	17	86	17,86			17	86		17
Cycloheximide [15, 17]	15,17		15,17	15		15,17			15,17	15
DEHP [89, 90]	90	89	89,90				89		89,90		90	90
Diazinon [88, 91]		88,91	88,91	91	91	88		91	88	91	91	91
DDT [92]	92		92						92	92	92	92	92
Fenoxaprop-ethyl [88]		88	88			88			88
Hexachlorocyclohexane [92]	92		92						92	92	92	92	92
Lindane [15]	15		15	15		15			15	15
Malathion [88, 91]		88,91	88,91	91	91	88		91	88	91	91	91
Methoxychlor [92]	92		92						92	92	92	92	92
MEHP [17, 90, 93]	17,90,93		17,90,93			17	93		17,90,93		90	90
Nanoparticles Au-Ag [94]		94	94				94		94
Nicotine [17, 86, 95, 96]	17,95,96	86	17,86,95,96	95	95	17	86,95		17,95,96	95	95,96	95,96	96	96
PCB mixtures [19, 97–102]	97-99	19,100-102	19,97-101	101	102	19,99,100	19,100	19	19,97-100	19,97,98, 100,101	19,97, 98,101	19,97,98, 100-102	98,101, 102
4-tert-octylphenol [103]	103		103						103	103	103	103	103
*Food*
Bisphenol A [89]		89	89				89		89
α-Chaconine [104]	104		104	104	104						104	104
Daidzein [105]		105	105				105		105	105	105	105
Deoxynivalenol [106–108]		106-108	106-108		106	108	108		106-108	108	107,108	107,108	107,108	107,108
Flavanones [109]		109	109				109		109	109	109	109
Genistein [15]	15		15	15		15			15	15
α-Solanine [104]	104		104	104	104						104	104
Solanidine-N-oxide [104]	104		104	104	104						104	104
Zearelanone [107, 110, 111]	110,111	107	107,110,111						107,110, 111		107,110	107,110	107	107
α-zearalenol [106, 107, 112]		106,107, 112	106,107		106				106, 107		107,112	107,112	107,112	107
β-zearalenol [106, 107]		106,107							106,107		107	107	107	107
*Drugs*
Busulfan [15]	15		15	15		15			15	15
Diethylstilbestro l [15, 17]	15,17		15,17	15		15,17			15,17	15
17β-Estradiol [17, 103]	17,103		17,103			17			17,103	103	103	103	103
Ionomycin [15]	15		15	15		15			15	15
Ketoconazole [15]	15		15	15		15			15	15
Methyl acetoacetate [15]	15		15	15		15			15	15
Mifepristone [15]	15		15	15		15			15	15
Nocodazole [15, 17]	15,17		15,17	15		15,17			15,17	15
Okadaic acid [95]	95		95				95		95
Piperazine [17]	17		17			17			17
Swainsonine [113]	113		113	113	113						113	113	113
Taxol [95]	95		95				95		95
*Cosmetics*
Butylparaben [15]	15		15	15		15			15	15
9-cis-Retinoic acid [114]	114		114								114	114
Retinoic acid [17]	17		17			17			17
*Occupational*
Acrylamide [17]	17		17			17			17

DDT: Dichlorodiphenyltrichloroethane; DEHP: Di-(2-ethylhexyl) phthalate; MEHP: Mono-(2-ethylhexyl) phthalate; PCB: polychlorinated biphenyl.

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ISSN: 1477-7827

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