Table 1 Characteristics of published studies that investigated the diagnostic value of a single measurement of serum activin-A in the diagnosis of pregnancy of unknown location (PUL), ectopic pregnancy (EP), abortion (AB) and intrauterine pregnancy (IUP)
From: Role of activins in embryo implantation and diagnosis of ectopic pregnancy: a review
| Research group | Publication year | Study design | Number of patients | First trimester gestational age | Cut-off value | AUC | Sensitivity | Specificity | Reference number |
|---|---|---|---|---|---|---|---|---|---|
| Florio et al. | 2007 | Prospective Observational | 536 PUL | Not reported | 370 pg/mL | 1.00 | 100% | 99.6% | [36] |
| Kirk et al. | 2009 | Prospective Observational | 141 PUL | Not reported | 370 pg/mL | 0.51 | 93% | 13% | [71] |
| Florio et al. | 2011 | Retrospective case–control | 30 EP & 30 IUP | Between 6 to 8 weeks | 430 pg/mL | 0.99 | 96.7% | 100% | [66] |
| Rausch et al. | 2011 | Retrospective case–control | 100 EP & 100 IUP | EP 45.15 ± 18.95; IUP 48.8 ± 18.34 days | 376.15 pg/mL | 0.78 | 80% | 72% | [22] |
| Warrick et al. | 2012 | Retrospective cohort study | 89 EP, 100 IUP & 100 AB | Median EP 5 weeks (1–10 weeks); AB and IUP 7 weeks (1–10 weeks) | < 260 pg/mL | 0.62 | 59.6% | 61% | [72] |
| Roghaei et al. | 2012 | Prospective case–control | 100 EP & 100 IUP | EP 6.32 ± 1.03 weeks; IUP 6.85 ± 1.82 weeks | 504 pg/mL | 0.981 | 97% | 93.5% | [69] |
| Daponte et al. | 2013 | Prospective case–control | 30 EP, 30 AB & 33 IUP | Between 6 to 8 weeks | 504 pg/mL | 0.979 | 87.9% | 100% | [67] |