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Table 2 Comparison of semen parameters between overall and 4 age groups among varicocele, smokers and alcohol users

From: Infertile men older than 40 years are at higher risk of sperm DNA damage

Group Parameter Overall ≤30 y 31 – 40 y <40 y >40 y
   (n = 472) (n = 69) (n = 298) (n = 367) (n = 105)
Varicocele (n = 253) Volume (mL) 3.1 ± 1.5 3.4 ± 1.5 3.1 ± 1.5 3.2 ± 1.5 3.1 ± 1.9
Concentration (X106/mL) 42.01 ± 50.58 33.43 ± 39.19 31.25 ± 37.10 31.67 ± 37.42 35.91 ± 44.58
Motility (%) 44.7 ± 19.7 46.3 ± 14.5 41.9 ± 19.9 42.5 ± 19.1 40.0 ± 22.1
Normal Morphology (%) 3.2 ± 2.9 3.1 ± 2.6 2.8 ± 2.8 2.9 ± 2.7 2.9 ± 2.8
TAC (micromolar trolox) 1964.42 ± 683.77 1985.10 ± 674.43 1842.23 ± 699.77 1985.10 ± 674.43 1977.51 ± 737.31
ROS (RLU/sec/X106) 267.7 (59.3; 1277.3) 1078.7 (37.7; 8611.2) 484.7 (94; 2144.3) 316.6 (90.5; 1197.7) 265.6 ± 234.8 (41; 1322.7)
Sperm DNA damage (%) 19.9 ± 15.3 18.9 ± 11.0 17.6 ± 11.1 17.7 ± 11.7 22.0 ± 15.9
Smokers (n = 100) Volume (mL) 3.1 ± 1.5 2.9 ± 1.4 3.0 ± 1.4 3.0 ± 1.4 2.6 ± 1.4
Concentration (X106/mL) 42.01 ± 50.58 30.86 ± 33.13 44.20 ± 50.23 42.14 ± 48.07 53.89 ± 77.41
Motility (%) 44.7 ± 19.7 45.2 ± 16.2 43.9 ± 17.5 44.2 ± 17.2 49.9 ± 25.5
Normal Morphology (%) 3.2 ± 2.9 3.8 ± 2.8 3.1 ± 3.0 3.2 ± 3.0 3.5 ± 2.6
TAC (micromolar trolox) 1964.42 ± 683.77 2146.67 ± 503.39 1842.23 ± 699.77 1883.75 ± 681.28 1683.08 ± 873.09
ROS (RLU/sec/X106) 267.7 (59.3; 1277.3) 1078.7 (37.7; 8611.2) 484.7 (94; 2144.3) 485 (90.6; 2238.3) 743.2 (215.8; 2744.2)
Sperm DNA damage (%) 19.9 ± 15.3 18.9 ± 11.0 17.6 ± 11.1 17.8 ± 11.0 16.0 ± 10.9
Alcohol users (n = 296) Volume (mL) 3.1 ± 1.5 3.1 ± 1.5 3.1 ± 1.5 3.1 ± 1.3 3.1 ± 1.7
Concentration (X106/mL) 42.01 ± 50.58 33.43 ± 39.19 31.25 ± 37.10 43.67 ± 51.69 41.07 ± 55.82
Motility (%) 44.7 ± 19.7 46.3 ± 14.5 41.9 ± 19.9 44.7 ± 20.2 45.3 ± 25.5
Normal Morphology (%) 3.2 ± 2.9 3.1 ± 2.6 2.8 ± 2.8 3.2 ± 2.9 3.2 ± 3.1
TAC (micromolar trolox) 1964.42 ± 683.77 2250.50 ± 513.30 1898.15 ± 672.16a 1944.48 ± 660.19 1940.45 ± 733.36
ROS (RLU/sec/X106) 267.7 (59.3; 1277.3) 390.6 (150.5; 2434.8) 244.4 (59.3; 866.8) 265.6 (66.2; 964.6) 346.9 (58.2; 1494.3)
  Sperm DNA damage (%) 19.9 ± 15.3 16.6 ± 12.3 19.8 ± 16.2 17.7 ± 11.7 24.1 ± 19.1
  1. The results are presented as mean ± SD for all the parameters except ROS which is presented as median (25th; 75th percentile).
  2. aP value <0.05 when 31-40 y group was compared with ≤30 y group.