From: Infertile men older than 40 years are at higher risk of sperm DNA damage
Group | Parameter | Overall | ≤30 y | 31 – 40 y | <40 y | >40 y |
---|---|---|---|---|---|---|
(n = 472) | (n = 69) | (n = 298) | (n = 367) | (n = 105) | ||
Varicocele (n = 253) | Volume (mL) | 3.1 ± 1.5 | 3.4 ± 1.5 | 3.1 ± 1.5 | 3.2 ± 1.5 | 3.1 ± 1.9 |
Concentration (X106/mL) | 42.01 ± 50.58 | 33.43 ± 39.19 | 31.25 ± 37.10 | 31.67 ± 37.42 | 35.91 ± 44.58 | |
Motility (%) | 44.7 ± 19.7 | 46.3 ± 14.5 | 41.9 ± 19.9 | 42.5 ± 19.1 | 40.0 ± 22.1 | |
Normal Morphology (%) | 3.2 ± 2.9 | 3.1 ± 2.6 | 2.8 ± 2.8 | 2.9 ± 2.7 | 2.9 ± 2.8 | |
TAC (micromolar trolox) | 1964.42 ± 683.77 | 1985.10 ± 674.43 | 1842.23 ± 699.77 | 1985.10 ± 674.43 | 1977.51 ± 737.31 | |
ROS (RLU/sec/X106) | 267.7 (59.3; 1277.3) | 1078.7 (37.7; 8611.2) | 484.7 (94; 2144.3) | 316.6 (90.5; 1197.7) | 265.6 ± 234.8 (41; 1322.7) | |
Sperm DNA damage (%) | 19.9 ± 15.3 | 18.9 ± 11.0 | 17.6 ± 11.1 | 17.7 ± 11.7 | 22.0 ± 15.9 | |
Smokers (n = 100) | Volume (mL) | 3.1 ± 1.5 | 2.9 ± 1.4 | 3.0 ± 1.4 | 3.0 ± 1.4 | 2.6 ± 1.4 |
Concentration (X106/mL) | 42.01 ± 50.58 | 30.86 ± 33.13 | 44.20 ± 50.23 | 42.14 ± 48.07 | 53.89 ± 77.41 | |
Motility (%) | 44.7 ± 19.7 | 45.2 ± 16.2 | 43.9 ± 17.5 | 44.2 ± 17.2 | 49.9 ± 25.5 | |
Normal Morphology (%) | 3.2 ± 2.9 | 3.8 ± 2.8 | 3.1 ± 3.0 | 3.2 ± 3.0 | 3.5 ± 2.6 | |
TAC (micromolar trolox) | 1964.42 ± 683.77 | 2146.67 ± 503.39 | 1842.23 ± 699.77 | 1883.75 ± 681.28 | 1683.08 ± 873.09 | |
ROS (RLU/sec/X106) | 267.7 (59.3; 1277.3) | 1078.7 (37.7; 8611.2) | 484.7 (94; 2144.3) | 485 (90.6; 2238.3) | 743.2 (215.8; 2744.2) | |
Sperm DNA damage (%) | 19.9 ± 15.3 | 18.9 ± 11.0 | 17.6 ± 11.1 | 17.8 ± 11.0 | 16.0 ± 10.9 | |
Alcohol users (n = 296) | Volume (mL) | 3.1 ± 1.5 | 3.1 ± 1.5 | 3.1 ± 1.5 | 3.1 ± 1.3 | 3.1 ± 1.7 |
Concentration (X106/mL) | 42.01 ± 50.58 | 33.43 ± 39.19 | 31.25 ± 37.10 | 43.67 ± 51.69 | 41.07 ± 55.82 | |
Motility (%) | 44.7 ± 19.7 | 46.3 ± 14.5 | 41.9 ± 19.9 | 44.7 ± 20.2 | 45.3 ± 25.5 | |
Normal Morphology (%) | 3.2 ± 2.9 | 3.1 ± 2.6 | 2.8 ± 2.8 | 3.2 ± 2.9 | 3.2 ± 3.1 | |
TAC (micromolar trolox) | 1964.42 ± 683.77 | 2250.50 ± 513.30 | 1898.15 ± 672.16a | 1944.48 ± 660.19 | 1940.45 ± 733.36 | |
ROS (RLU/sec/X106) | 267.7 (59.3; 1277.3) | 390.6 (150.5; 2434.8) | 244.4 (59.3; 866.8) | 265.6 (66.2; 964.6) | 346.9 (58.2; 1494.3) | |
Sperm DNA damage (%) | 19.9 ± 15.3 | 16.6 ± 12.3 | 19.8 ± 16.2 | 17.7 ± 11.7 | 24.1 ± 19.1 |