Skip to main content

Table 2 Maximum concentrations of individual compounds tested in MVLN in vitro bioassays, induction relative to an E2 standard, and relative potency (REP) estimates

From: Estrogenic potency of bisphenol S, polyethersulfone and their metabolites generated by the rat liver S9 fractions on a MVLN cell using a luciferase reporter gene assay

Compounds

Max. Conc. (μM)

%-E2maxa

Relative potency (REP)

REP50b

REP20-80c

BPA

0.5

48.8

4.25 × 10−5

2.17 × 10−4 – 8.32 × 10−6

BPS

0.5

19.2

4.09 × 10−9

2.25 × 10−6 – 7.41 × 10−12

PES

0.5

-

NAd

 
  1. a%-E2max = Maximum response against the response at the highest concentration of E2 (E2max).
  2. bSingle point estimate of REP performed for the response of 50%-E2max.
  3. cREPs reported as the range of REP estimates generated from multiple points over a response range from 20- to 80%-E2max.
  4. dNA: not analyzed because the dose–response relationship was insufficient for estimation.