Pregnancy outcome in IVF/ICSI cycles. (a) The IVF/ICSI outcome in the ANA + group and the ANA-group. In the ANA + group, the implantation rate (9.09% vs. 36.8%) and the clinical pregnancy rate (17.3% vs. 56.5%) decreased significantly, and the early miscarriage rate (44.4% vs. 9.62%) increased markedly more than in the ANA- group. (b) The IVF/ICSI outcome in the Titre ≤1:320 subgroup and the Titre > 1:320 subgroup. No significant differences were found between the two subgroups in the implantation rate, the clinical pregnancy rate and the early miscarriage rate. * P < 0.05, ** P < 0.01.