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Table 4 Significant canonical pathways associated with seminal plasma

From: Proteomic analysis of seminal fluid from men exhibiting oxidative stress

Ingenuity Canonical Pathways Ratio Proteins
Eumelanin Biosynthesis 5E-01 MIF
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis 1.35E-02 MIF, FN1
Intrinsic Prothrombin Activation Pathway 8.33E-02 KLK3
MSP-RON Signaling Pathway 5.88E-02 KLK3
MIF-mediated Glucocorticoid Regulation 4.76E-02 MIF
MIF Regulation of Innate Immunity 4E-02 MIF
Thyroid Cancer Signaling 3.57E-02 KLK3
Neurotrophin/TRK Signaling 2.5E-02 KLK3
Atherosclerosis Signaling 1.89E-02 CLU
Prostate Cancer Signaling 1.79E-02 KLK3
LXR/RXR Activation 1.56E-02 CLU
Human Embryonic Stem Cell Pluripotency 1.56E-02 KLK3
IL-12 Signaling and Production in Macrophages 1.54E-02 CLU
Hepatic Fibrosis / Hepatic Stellate Cell Activation 1.2E-02 FN1
Production of Nitric Oxide and Reactive Oxygen Species in Macrophages 1.11E-02 CLU
Acute Phase Response Signaling 1.06E-02 FN1
Clathrin-mediated Endocytosis Signaling 1.06E-02 CLU
ILK Signaling 1.05E-02 FN1
Actin Cytoskeleton Signaling 9.01E-03 FN1
  1. Pathways associated with proteins specific to ROS- group are in bold. MSP-RON Macrophage-stimulating protein- transmembrane receptor kinase, MIF Macrophage migration inhibitory factor, TRK Tyrosine kinase, LXR/RXR Liver X receptor / retinoid X receptor, IL Interleukin, KLK3 Prostate specific antigen, CLU Clusterin, FN1 Fibronectin 1 isoform 3 preprotein.