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Table 4 Significant canonical pathways associated with seminal plasma

From: Proteomic analysis of seminal fluid from men exhibiting oxidative stress

Ingenuity Canonical Pathways

Ratio

Proteins

Eumelanin Biosynthesis

5E-01

MIF

Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis

1.35E-02

MIF, FN1

Intrinsic Prothrombin Activation Pathway

8.33E-02

KLK3

MSP-RON Signaling Pathway

5.88E-02

KLK3

MIF-mediated Glucocorticoid Regulation

4.76E-02

MIF

MIF Regulation of Innate Immunity

4E-02

MIF

Thyroid Cancer Signaling

3.57E-02

KLK3

Neurotrophin/TRK Signaling

2.5E-02

KLK3

Atherosclerosis Signaling

1.89E-02

CLU

Prostate Cancer Signaling

1.79E-02

KLK3

LXR/RXR Activation

1.56E-02

CLU

Human Embryonic Stem Cell Pluripotency

1.56E-02

KLK3

IL-12 Signaling and Production in Macrophages

1.54E-02

CLU

Hepatic Fibrosis / Hepatic Stellate Cell Activation

1.2E-02

FN1

Production of Nitric Oxide and Reactive Oxygen Species in Macrophages

1.11E-02

CLU

Acute Phase Response Signaling

1.06E-02

FN1

Clathrin-mediated Endocytosis Signaling

1.06E-02

CLU

ILK Signaling

1.05E-02

FN1

Actin Cytoskeleton Signaling

9.01E-03

FN1

  1. Pathways associated with proteins specific to ROS- group are in bold. MSP-RON Macrophage-stimulating protein- transmembrane receptor kinase, MIF Macrophage migration inhibitory factor, TRK Tyrosine kinase, LXR/RXR Liver X receptor / retinoid X receptor, IL Interleukin, KLK3 Prostate specific antigen, CLU Clusterin, FN1 Fibronectin 1 isoform 3 preprotein.