Figure 1

AMH levels and menarcheal age in donors with normal and PDFOR. (A) AMH levels, based on CGG_n on the FMR1 gene in donors with normal FOR: AMH levels in the whole group differed significantly, based on FMR1 (P = 0.012), with the difference primarily being due to Asian patients (see text). Independent of FMR1, the figure demonstrates similar AMH levels in Caucasian and African donors. Asian women with low (CGG_n<26) allele, however, demonstrate significantly higher AMH (P = 0.009) than Caucasians and Africans combined, and Asian women with CGG_n=≥26 (P = 0.006); (B) demonstrates AMH levels in donors with PDFOR: here, all three races demonstrate lower AMH with low FMR1 allele, the difference almost reaching significance (P = 0.057); (C) demonstrates that with normal FOR age of menarche did not differ based on either race or FMR1 status; (D) in contrast, demonstrates with PDFOR there was significant interaction between CGG_n and race (P = 0.018), with African donors reaching menarche at later age than Caucasians (P = 0.017) and Asians (P = 0.025), and amongst African donors those with CGG_n<26 reaching menarche later than those with CGG_n≥26 (P = 0.019).