Association between the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) rs4073366 polymorphism and ovarian hyperstimulation syndrome during controlled ovarian hyperstimulation

Table 4 Adjusted regression of demographic, clinical and genetic predictors of estradiol level on day of hCG, follicle count, and egg count*

Factor	Estradiol Level on Day of hCG (N = 157)^a			Number of Follicles (N = 155)^b			Number of Eggs Retrieved (N = 160)^c
Factor	Estimate	95% CI	P-Value	Estimate	95% CI	P-Value	Estimate	95% CI	P-Value
Age	−48.2	−90.3, -6.1	0.03	0.939	0.918, 0.961	<0.0001	0.951	0.927, 0.977	0.0002
Day 3 FSH level	−10.3	−38.0, 17.3	0.46	0.976	0.958, 0.994	0.0097	0.953	0.930, 0.977	0.0002
Day 3 Estradiol level	−2.5	−7.7, 2.7	0.34	0.999	.997, 1.002	0.57	0.998	0.995, 1.000	0.08
insLQ/insLQ, GG	5.9	−818.3, 830.2	0.98	0.963	0.617, 1.503	0.32	0.647	0.380, 1.111	0.11
no-insLQ/insLQ, GG	−197.2	−538.9, 144.4	0.26	0.909	0.755, 1.096	0.87	0.952	0.772, 1.174	0.64
no-insLQ/no-insLQ, CC	−784.1	−1,682.0, 113.7	0.09	0.903	0.557, 1.63	0.68	0.665	0.372, 1.189	0.17
no-insLQ/no-insLQ, CG	163.8	−224.3, 551.9	0.41	1.210	0.985, 1.488	0.07	1.211	0.963, 1.523	0.10

* Estimates adjusted for all other variables presented.
^a Linear regression with estimates of change in mean estradiol levels (pg/ml).
^b Negative binomial regression with estimates of relative odds of number of follicles.
^c Negative binomial regression with estimates of relative odds of number of eggs retrieved.

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