Figure 3
Representative photomicrographs of ghrelin O -acyltransferase (GOAT) immunoreactivity in prostate cancer specimens and in benign prostatic hyperplasia (BPH). Diffuse cytoplasmic staining was detected in (A) poorly differentiated cancer specimens, (B) Gleason grade 4 + 5 and (C) Gleason grade 4+ 2. (D) No immunoreactivity was detected in some cancers (Gleason grade 3 +3) demonstrating the heterogeneity of GOAT expression in prostate cancer. More granular dot-like staining was present in (E, F) BPH sections. Scale bars are as indicated on micrographs.