Obstetric complications in women with polycystic ovary syndrome: a systematic review and meta-analysis

Qin, Jun Z; Pang, Li H; Li, Mu J; Fan, Xiao J; Huang, Ru D; Chen, Hong Y

doi:10.1186/1477-7827-11-56

Reproductive Biology and Endocrinology

Table 2 Main characteristics of included studies

From: Obstetric complications in women with polycystic ovary syndrome: a systematic review and meta-analysis

Study no.	Author	Year	Study design	Study center	Study size	No. of PCOS/control	Outcomes included	PCOS group	Control group	Multiple pregnancies	Notions
1	Diamant [21]	1982	Retrospective	single center	72	33/39	PE, birthweight	Pregnant by ovulation induction	Anovulatory women pregnant by ovulation	Included,but equal Incidence	Matched for: age, similar parity
2	Levran [22]	1990	Retrospective	single center	171	76/95	GDM	Pregnant by CC,,hMG,or spontaneous	Normal pregnant Women	Not stated	Matched for age and BMI
3	Wortsman [23]	1991	Retrospective	multicenter	2359	53/2,306	GDM, birthweight	Pregnant by CC, hMG, dexamethasone, bromocriptine	Normal pregnant Women	Included,no significantly difference	Matched for age and BMI
4	Cardenas [24]	1996	Retrospective	single center	109	77/31	GDM, Birthweight	Pregnant by ovulation induction	Normal pregnant Women	Not included	matched for age and gravidity
5	Urman [25]	1997	Retrospective	single center	147	47/100	GDM,PIH, PE,preterm, NICU	Pregnant by CC,,hMG, dexamethasone,IVF	Normal pregnant Women	Not included	matched for age and gravidity, PCOS higher BMI
6	Lesser [26]	1997	Retrospective	single center	68	24/44	GDM	Pregnant by CC, hMG	infertility women pregnant by CC,hMG	Not stated	PCOS higher BMI
7	Fridstrom [27]	1999	Retrospective	single center	99	33/66	GDM,PIH,PE,birthweight, Cesarean section,NICU	Pregnant by IVF, ovulation Induction	Normal pregnant women	Included,,no significantly difference	matched for age and treatment
8	Radon [28]	1999	Retrospective	single center	88	22/66	GDM,PE, Birthweight	Pregnant by CC, hMG, IVF,or spontaneous	Normal pregnant Women	Not included	Matched for age and BMI
9	Kashyap [29]	2000	Retrospective	single center	49	22/27	PIH	Pregnant by hMG, ovulation Induction	Pregnant by hMG, IVF/IUI	Not stated	Similar BMI, age, parity
10	Vollenhoven [30]	2000	Retrospective	single center	132	60/72	GDM,PIH, preterm, birthweight, Cesarean section	Pregnant by ovulation induction	Normal pregnant Women	Included,no significantly difference	matched for age, BMI
11	Mikola [31]	2001	Retrospectiv	multicenter	836	80/728	GDM,PE, preterm, birthweight, Cesarean section	Pregnant by CC, gonadotrophins ,IVF	Normal pregnant Women	only singleton result included	PCOS higher BMI
12	Bjercke [11]	2002	Prospective	single center	407	52/355	GDM,PIH,PE,preterm, birthweight, Cesarean section, NICU	Pregnant by CC, hMG, IVF, IUI	Pregnant by ART	Not included	PCOS higher BMI
13	Haakova [32]	2003	Retrospective	Multicenter	132	66/66	GDM,PIH, preterm, birthweight, Cesarean section	Pregnant by ovulation Induction	Normal pregnant Women	Included,no significantly difference	Matched for age and BMI
14	Turhan [33]	2003	Retrospective	single center	174	38/136	GDM,PIH,PE,preterm, birthweight, Cesarean section,NICU	Not stated	Normal pregnant Women	Not included	matched for age
15	Weerakiet [34]	2004	Retrospective	single center	311	47/264	GDM,PIH,PE, preterm, birthweight, Cesarean section	Pregnant by CC, IVF, ovarian drilling	Normal pregnant Women	Not included	PCOS higher BMI
16	Sir-Petermann [35]	2005	Prospective	single center	227	47/180	GDM,PE, preterm, birthweight, NICU	Not stated	Normal pregnant Women	Not included	matched for age,BMI
17	Al-Ojaimi [36]	2006	Prospectiv	single center	513	134/479	GDM,PIH,PE, preterm, birthweight	treated with laparoscopic ovarian drilling	Normal pregnant Women	Not included	PCOS higher BMI
18	Hu [37]	2007	Prospective	single center	44	22/22	PIH, Birthweight	Spontaneous	Normal pregnant Women	Not included	matched for age,BMI, parity
19	Sir-Petermann [38]	2007	Prospective	single center	99	48/51	GDM,PIH	Not stated	Normal pregnant Women	Not stated	matched for age
20	Maliqueo [39]	2009	Prospective	single center	64	30/34	Birthweight	Spontaneous	Normal pregnant Women	Not included	PCOS higher BMI
21	Palomba [14]	2010	Prospective	single center	162	93/69	GDM,PIH,PE, preterm, Cesarean section	Spontaneous	Normal pregnant Women	Not included	matched for age, BMI and parity
22	Altieri [40]	2010	Retrospective	single center	174	15/159	GDM,PIH,PE, preterm, birthweight, Cesarean section	Spontaneous, ovulation induction, ART	Normal pregnant Women	Not included	matched for age, BMI and parity
23	Li [41]	2010	Prospective	single center	104	34/70	PE,preterm, birthweight	Pregnant by ART, Spontaneous	Normal pregnant Women	Not included	PCOS higher BMI
24	Roos [42]	2011	Prospective	single center	1195123	3787/ 1 191 336	GDM,PE ,preterm, Cesarean section	Pregnant by ART	Normal pregnant Women	Not included	PCOS higher BMI
25	Dmitrovic [43]	2011	Prospective	single center	34	17/17	GDM, Birthweight	Not stated	Not stated	Not included	results adjust for BMI
26	Han [44]	2011	Retrospective	Not stated	1339	336/1003	PIH,preterm	Pregnant by ovulation induction, ART	pregnant by ovulation induction, ART	Included,no significantly difference	matched by age, PCOS higher BMI
27	Reyes-Munoz [45]	2012	Retrospective	single center	104	52/52	GDM,PE, preterm, birthweight	Achieved pregnancy after OCs,CC	Normal pregnant Women	Not included	matched by age, parity, BMI

GDM gestational diabetes mellitus, PIH pregnancy-induced hypertension, PE preeclampsia, NICU admission to a neonatal intensive care unit, ART assisted reproductive technology, IVF In vitro fertilization, CC clomifene, OC Oral contraceptive. ‘See Additional file 1: Table S1’.

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ISSN: 1477-7827

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