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Table 2 Main characteristics of included studies

From: Obstetric complications in women with polycystic ovary syndrome: a systematic review and meta-analysis

Study no. Author Year Study design Study center Study size No. of PCOS/control Outcomes included PCOS group Control group Multiple pregnancies Notions
1 Diamant [21] 1982 Retrospective single center 72 33/39 PE, birthweight Pregnant by ovulation induction Anovulatory women pregnant by ovulation Included,but equal Incidence Matched for: age, similar parity
2 Levran [22] 1990 Retrospective single center 171 76/95 GDM Pregnant by CC,,hMG,or spontaneous Normal pregnant Women Not stated Matched for age and BMI
3 Wortsman [23] 1991 Retrospective multicenter 2359 53/2,306 GDM, birthweight Pregnant by CC, hMG, dexamethasone, bromocriptine Normal pregnant Women Included,no significantly difference Matched for age and BMI
4 Cardenas [24] 1996 Retrospective single center 109 77/31 GDM, Birthweight Pregnant by ovulation induction Normal pregnant Women Not included matched for age and gravidity
5 Urman [25] 1997 Retrospective single center 147 47/100 GDM,PIH, PE,preterm, NICU Pregnant by CC,,hMG, dexamethasone,IVF Normal pregnant Women Not included matched for age and gravidity, PCOS higher BMI
6 Lesser [26] 1997 Retrospective single center 68 24/44 GDM Pregnant by CC, hMG infertility women pregnant by CC,hMG Not stated PCOS higher BMI
7 Fridstrom [27] 1999 Retrospective single center 99 33/66 GDM,PIH,PE,birthweight, Cesarean section,NICU Pregnant by IVF, ovulation Induction Normal pregnant women Included,,no significantly difference matched for age and treatment
8 Radon [28] 1999 Retrospective single center 88 22/66 GDM,PE, Birthweight Pregnant by CC, hMG, IVF,or spontaneous Normal pregnant Women Not included Matched for age and BMI
9 Kashyap [29] 2000 Retrospective single center 49 22/27 PIH Pregnant by hMG, ovulation Induction Pregnant by hMG, IVF/IUI Not stated Similar BMI, age, parity
10 Vollenhoven [30] 2000 Retrospective single center 132 60/72 GDM,PIH, preterm, birthweight, Cesarean section Pregnant by ovulation induction Normal pregnant Women Included,no significantly difference matched for age, BMI
11 Mikola [31] 2001 Retrospectiv multicenter 836 80/728 GDM,PE, preterm, birthweight, Cesarean section Pregnant by CC, gonadotrophins ,IVF Normal pregnant Women only singleton result included PCOS higher BMI
12 Bjercke [11] 2002 Prospective single center 407 52/355 GDM,PIH,PE,preterm, birthweight, Cesarean section, NICU Pregnant by CC, hMG, IVF, IUI Pregnant by ART Not included PCOS higher BMI
13 Haakova [32] 2003 Retrospective Multicenter 132 66/66 GDM,PIH, preterm, birthweight, Cesarean section Pregnant by ovulation Induction Normal pregnant Women Included,no significantly difference Matched for age and BMI
14 Turhan [33] 2003 Retrospective single center 174 38/136 GDM,PIH,PE,preterm, birthweight, Cesarean section,NICU Not stated Normal pregnant Women Not included matched for age
15 Weerakiet [34] 2004 Retrospective single center 311 47/264 GDM,PIH,PE, preterm, birthweight, Cesarean section Pregnant by CC, IVF, ovarian drilling Normal pregnant Women Not included PCOS higher BMI
16 Sir-Petermann [35] 2005 Prospective single center 227 47/180 GDM,PE, preterm, birthweight, NICU Not stated Normal pregnant Women Not included matched for age,BMI
17 Al-Ojaimi [36] 2006 Prospectiv single center 513 134/479 GDM,PIH,PE, preterm, birthweight treated with laparoscopic ovarian drilling Normal pregnant Women Not included PCOS higher BMI
18 Hu [37] 2007 Prospective single center 44 22/22 PIH, Birthweight Spontaneous Normal pregnant Women Not included matched for age,BMI, parity
19 Sir-Petermann [38] 2007 Prospective single center 99 48/51 GDM,PIH Not stated Normal pregnant Women Not stated matched for age
20 Maliqueo [39] 2009 Prospective single center 64 30/34 Birthweight Spontaneous Normal pregnant Women Not included PCOS higher BMI
21 Palomba [14] 2010 Prospective single center 162 93/69 GDM,PIH,PE, preterm, Cesarean section Spontaneous Normal pregnant Women Not included matched for age, BMI and parity
22 Altieri [40] 2010 Retrospective single center 174 15/159 GDM,PIH,PE, preterm, birthweight, Cesarean section Spontaneous, ovulation induction, ART Normal pregnant Women Not included matched for age, BMI and parity
23 Li [41] 2010 Prospective single center 104 34/70 PE,preterm, birthweight Pregnant by ART, Spontaneous Normal pregnant Women Not included PCOS higher BMI
24 Roos [42] 2011 Prospective single center 1195123 3787/ 1 191 336 GDM,PE ,preterm, Cesarean section Pregnant by ART Normal pregnant Women Not included PCOS higher BMI
25 Dmitrovic [43] 2011 Prospective single center 34 17/17 GDM, Birthweight Not stated Not stated Not included results adjust for BMI
26 Han [44] 2011 Retrospective Not stated 1339 336/1003 PIH,preterm Pregnant by ovulation induction, ART pregnant by ovulation induction, ART Included,no significantly difference matched by age, PCOS higher BMI
27 Reyes-Munoz [45] 2012 Retrospective single center 104 52/52 GDM,PE, preterm, birthweight Achieved pregnancy after OCs,CC Normal pregnant Women Not included matched by age, parity, BMI
  1. GDM gestational diabetes mellitus, PIH pregnancy-induced hypertension, PE preeclampsia, NICU admission to a neonatal intensive care unit, ART assisted reproductive technology, IVF In vitro fertilization, CC clomifene, OC Oral contraceptive. ‘See Additional file 1: Table S1’.