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Table 3 COH outcome

From: First intention IVF protocol for polycystic ovaries: does oral contraceptive pill pretreatment influence COH outcome?

  Non OCP group OCP group p-value
Clinical outcome Cycles (n) 57 45  
  % cancellation before retrieval 15.8% (n = 9) 13.3% (n = 6) NS
  % oocytes retrieval (n) 84.2% (n = 48) 86.7% (n = 39) NS
  r-FSH starting dose (IU) 125 [100–200] 125 [100–150] NS
  Duration of stimulation (days) 11 [8.45-15.55] 11 [9.0-14.0] NS
  Total dose of r-FSH (IU) 1437.5 [872.5-2555] 1462.5 [1000–2250] NS
  % OHSS 16.6% (n = 8) 10.2% (n = 4) NS
  Days of GnRH agonist (n) 25 [20–33] 24 [21–29] P = 0.011
Endometrium thickness D1 (mm) 2.0 [2.0-5.8] 3.0 [2.0-6.3] P = 0.001
  HCG-D (mm) 11.0 [8.5-14.8] 10.0 [7.9-13.0] P = 0.002
  Delta (mm) (HCG-D – D1) 8.0 [4.4-12] 6.5 [2.3-10.3] P < 0.0001
Oocytes Total oocytes (n) 14 [7.5-24.0] 14 [7.0-27.0] NS
  Lysed oocytes (n) 1 [0–5.6] 2 [0–6.0] NS
  Meta II oocytes (n) 11 [4.0-19.0] 8 [5.0-22.0] NS
  Ratio meta II oocytes/≥ 15 mm follicles 1.44 (+/−0.92) 1.32 (+/−0.80) NS
Embryos Embryos (n) 6 [0.5-14.5] 5 [0.0-13.0] NS
  Fertilization rate 63% (+/−21) 56% (+/−26) NS
  “Top quality” embryos (n) 2 [0.0-7.0] 1 [0.0-8.0] NS
  Cycles with embryo transfer (n) 46 33  
  One embryo transferred (%) 6.5 (n = 3) 18.2 (n = 6) NS
  Two embryos transferred (%) 87 (n = 42) 81.8 (n = 27) NS
  Three embryos transferred (%) 2.2 (n = 1) 0 (n = 0) NS
  Cycles with freezing (%) 58.3 (n = 28) 51.2 (n = 20) NS
  Frozen embryos (n) 4 [1.0-11.0] 3.5 [1.0-10.0] NS
  Recovery rate after thawing 72,8% 77,9% NS
  Frozen-thawed embryo transfers (n) 19 21  
  Clinical pregnancy rate per frozen-thawed embryo transfer 31,6% (n = 6) 38% (n = 8) NS
  Ongoing pregnancy rate per frozen-thawed embryo transfer 31,6% (n = 6) 38% (n = 8) NS
  1. COH controlled ovarian hyperstimulation, r-FSH recombinant FSH, OHSS Ovarian hyperstimulation syndrome, D1 first day of controlled ovarian hyperstimulation, HCG-D HCG injection day. meta II: metaphase II. Continuous variables are expressed as medians [5th – 95th percentiles].