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Table 5 Ovarian response and clinical outcomes: step-down or fixed dose rFSH from day 8 (Analysis Set 2)

From: Corifollitropin alfa or rFSH treatment flexibility options for controlled ovarian stimulation: a post hocanalysis of the Engage trial

 

Corifollitropin alfa

rFSH

 

Step-down

Fixed dose

Step-down

Fixed dose

 

n = 138

n = 409

n = 79

n = 430

Duration of stimulation, days, mean (SD)

10.0 (1.1)

10.1 (1.3)

9.8 (1.1)

9.8 (1.0)

Follicles on day 8 ≥11 mm, mean (SD)

15.2 (5.1)

10.5 (5.4)

14.1 (5.3)

9.6 (4.7)

E 2 on day 8, pmol/l, median (P5, P95)

4734

2341

4184

2415

(1431, 8918)

(738, 6019)

(995, 10,606)

(910, 6276)

Follicles on day of hCG ≥11 mm, mean (SD)

20.5 (5.3)

14.1 (6.2)

18.0 (6.1)

12.6 (5.3)

Serum E 2 on day of hCG, pmol/l, median (P5, P95)

7817

4147

7212

4221

(2393, 13,799)

(1497, 10,239)

(1655, 16,772)

(1696, 9726)

No. of oocytes retrieved, mean (SD)

19.4 (8.1)

12.4 (7.4)

16.5 (6.4)

11.8 (6.4)

No. of embryos obtained on day 3, mean (SD)

11.8 (6.0)

7.5 (5.2)

10.2 (5.2)

7.1 (4.5)

No. of GQEs obtained on day 3, mean (SD)

6.5 (5.7)

4.1 (3.8)

5.5 (4.4)

4.3 (3.7)

No. of GQEs transferred, mean (SD)

1.1 (0.8)

1.3 (0.8)

1.3 (0.7)

1.3 (0.8)

Cycle cancellation rate, n (%)

15 (10.9)

30 (7.3)

4 (5.1)

23 (5.3)

  1. SD standard deviation, P5 5th percentile, P95 95th percentile, E 2  estradiol, GQEs good-quality embryos.