Figure 5
From: Proteomic analysis of human spermatozoa proteins with oxidative stress
CREM signaling in the testis. Proteins in red or blue are the ones over or underexpressed in spermatozoa from the ROS + compared to ROS- group. The color levels in the tubes reflect their expression levels (red-overexpressed and blue underexpressed). B = Binding; Z = catalysis; T = transformation and TR = transcription regulation. The figure shows the generic enxzymes (Adenylate cyclase, LDHC, ACE1, HXK2); Protein kinases (PKA-cat (cAMP –dependent and TSSK2); CREM activators and repressors; generic binding proteins (ACT, CPB and Tnp1 and PKA-reg (cAMP –dependent) and proteins (HILS1 and ODF1) involved in the CREM signaling in the testis. CREM = cAMP responsive element modulator; ACE = Angiotensin I converting isoform 1 precursor; ODF1 = outer dense fiber of sperm tails 1; LDHC = L- lactate dehydrogenase C.