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Table 2 Detailed list of classification of 35 proteins based on their presence, abundance, and differential expression

From: Functional proteomic analysis of seminal plasma proteins in men with various semen parameters

No.

Protein Names

NCBI Accession No.

UniProt Accession No.

No. of samples

Proteins present in groups

Low abundant proteins (SC ≤ 10)

Differentially Expressed Proteins (in NA, OA, and ON) compared to NN

Significant proteins in groups

1

prolactin-induced protein

4505821

P12273

12

NN(5), NA(4), OA(2), ON(1)

  

NN, NA, OA, ON

2

semenogelin II precursor

4506885

Q02383

12

NN(5), NA(4), OA(2), ON(1)

  

NN, NA, OA, ON

3

albumin preproprotein

4502027

P02768

12

NN(5), NA(4), OA(2), ON(1)

  

NN, NA, OA, ON

4

lactotransferrin

54607120

P02788

12

NN(5), NA(4), OA(2), ON(1)

  

NN, NA, OA, ON

5

epididymal secretory protein E1 precursor

5453678

P61916

12

NN(5), NA(4), OA(2), ON(1)

  

NN, NA, OA, ON

6

extracellular matrix protein 1 isoform 1 precursor

221316614

Q16610

12

NN(5), NA(4), OA(2), ON(1)

  

NN, NA, OA, ON

7

prosaposin isoform a preproprotein

11386147

P07602

12

NN(5), NA(4), OA(2), ON(1)

  

NN, NA, OA, ON

8

cathepsin D preproprotein

4503143

P07339

12

NN(5), NA(4), OA(2), ON(1)

  

NN, NA, OA, ON

9

prostate specific antigen isoform 1 preproprotein

4502173

Q546G3

12

NN(5), NA(4), OA(2), ON(1)

 

↑ in OA

NN, NA, OA, ON

10

zinc alpha-2-glycoprotein 1

4502337

P25311

12

NN(5), NA(4), OA(2), ON(1)

 

↑ in ON

NN, NA, OA, ON

11

clusterin isoform 1

42716297

P10909

12

NN(5), NA(4), OA(2), ON(1)

Low in ON

↓ in ON

NN, NA, OA

12

mucin 6, gastric

151301154

Q6W4X9

11

NN(4), NA(4), OA(2), ON(1)

 

↓ in NA

NN, NA, OA, ON

13

cystatin S precursor

4503109

P01036

11

NN(4), NA(4), OA(2), ON(1)

Low in ON

↓ in NA, OA, ON

NN, NA, OA

14

galectin 3 binding protein

5031863

Q08380

11

NN(5), NA(3), OA(2), ON(1)

Low in OA and ON

↓ in OA, ON

NN, NA

15

semenogelin I isoform b preproprotein

38049014

P04279

10

NN(3), NA(4), OA(2), ON(1)

 

↑ in OA

NN, NA, OA, ON

16

prostatic acid phosphatase precursor

6382064

P15309

10

NN(4), NA(3), OA(2), ON(1)

Low in ON

↓in NA, ON

NN, NA, OA

17

cystatin C precursor

4503107

P01034

9

NN(4), NA(3), OA(1), ON(1)

 

↓in OA

NN, NA, OA, ON

18

tissue inhibitor of metalloproteinase 1 precursor

4507509

Q6FGX5

8

NN(3), NA(3), OA(1), ON(1)

 

↑ in ON

NN, NA, OA, ON

19

beta 2 microglobulin precursor

4757826

P61769

8

NN(3), NA(3), OA(1), ON(1)

Low in OA

↓ in OA; Up in ON

NN, NA, ON

20

DJ-1 protein

31543380

Q99497

6

NN(2), NA(3), ON(1)

 

↑ in NA, ON

NN, NA, ON

21

ankyrin repeat domain 11

56676397

Q6UB99

4

NA(1), OA(2), ON(1)

Low in NA and ON

↓ in OA, ON

OA

22

orosomucoid 1 precursor

167857790

P02763

2

NN(2), NA(1)

Low in NA

↓in NA

NN

23

serine proteinase inhibitor, clade A, member 1

50363217

P01009

8

NN(3), NA(3), OA(1), ON(1)

 

↑ in NA,ON; ↓ in OA

NA, OA, ON

24

transferrin

4557871

Q06AH7

6

NN(2), NA(3), OA(1)

Low abundant

↑ in NA, OA

NONE

25

secretory leukocyte peptidase inhibitor precursor

4507065

P03973

5

NN(1), NA(3), OA(1)

Low abundant

↑ in NA, OA

NONE

26

ubiquitin and ribosomal protein S27a precursor

4506713

P62979

4

NN(2), NA(1), OA(1)

Low abundant

↓ in NA, OA

NONE

27

protein tyrosine phosphatase, receptor type, sigma isoform 1 precursor

104487006

Q13332

4

NN(1), NA(2), ON(1)

Low abundant

↑ in NA, ON

NONE

28

acidic epididymal glycoprotein-like 1 isoform 1 precursor

25121982

P54107

3

NN(2), NA(1)

Low abundant

↓in NA

NONE

29

prostaglandin H2 D-isomerase

32171249

P41222

5

NN(2), NA(2), OA(1)

Low abundant

 

NONE

30

cathepsin B preproprotein

4503139

P07858

6

NN(3), NA(3)

Low abundant

 

NONE

31

expressed in prostate and testis

19923082

Q8WXA2

4

NN(2), NA(1), OA(1)

Low abundant

 

NONE

32

orosomucoid 2

4505529

P19652

1

NN(1)

Low abundant

 

NONE

33

CD177 molecule

110735433

Q8N6Q3

3

NA(1), OA(1), ON(1n with (1))

Low abundant

 

NONE

34

carboxypeptidase E preproprotein

4503009

P16870

9

NN(3), NA(3), OA(2), ON(1)

Low in OA and ON

 

NN, NA

35

fibronectin 1 isoform 2 preproprotein

47132551

P02751

10

NN(4), NA(4), OA(1), ON(1)

Low in ON

 

NN, NA, OA

  1. NN = normal sperm count and normal morphology; NA = normal sperm count and abnormal morphology; ON = oligozoospermia and normal morphology; OA = oligozoospermia and abnormal morphology; number in the parenthesis indicates the number of samples.