Figure 5

Hypoxia inducible factor 1α and vascular endothelial growth factor luteal immunoreactivity in cycling sheep at a high altitude. HIF-1α (panel A) and VEGF (panel B) immunostaining density were evaluated in corpora lutea at day 5 after ovulation in non-conceptional reproductive cycles in sheep at a high altitude either unsupplemented (HH: high-altitude natives; LH: low-altitude natives) or supplemented daily (HHV: high-altitude natives; LHV: low-altitude natives) with vitamins C and E. Groups LL and LLV correspond to the control cycling sheep at a low altitude without and with vitamin supplementation, respectively. The different letters above the columns indicate significant differences among the groups (P<0.05, Duncan`s test).