Figure 7From: Protective effects of nuclear factor erythroid 2-related factor 2 on whole body heat stress-induced oxidative damage in the mouse testisProposed model of Nrf2-mediated protection to whole body heat stress in mice testes. ROS production induced by heat stress was inhibited by the antioxidative system in cytoplasm. Increased ROS stimulated Nrf2-antioxidant system and up-regulated CuZn-SOD concentration in spermatogonia. Thereby, the antioxidative system was enhanced and efficiently protected testes against oxidative damage.Back to article page