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Figure 3 | Reproductive Biology and Endocrinology

Figure 3

From: Combination of a GnRH agonist with an antagonist prevents flare-up effects and protects primordial ovarian follicles in the rat ovary from cisplatin-induced toxicity: a controlled experimental animal study

Figure 3

Ovarian histological study and follicle counting. Histological examination of ovaries, 100×. Numerous follicles with normal morphology in the ovaries of rats in the control group; an obvious decline of follicles and the destruction of the ovarian structure in the CDDP group; a remarkable sparing of primordial follicles in the GnRHa group, the GnRHant group and both combination groups. Arrow—primordial follicle; PF—primary follicle; aPF—atretic primary follicle; SF—secondary follicle; aSF—atretic primary follicle (A). Primordial, growing, and mature follicle counts of rats in the control, CDDP, GnRHa, GnRHant and combination groups. **P<0.01, compared to the control group; ## P<0.01, compared to the CDDP group; §§ P<0.01, compared to the combination (lng) group (B).

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