Figure 6
The effects of IMD receptor antagonists on the inhibition of uterine contraction by IMD. Decreased amplitude (A) and frequency (B) were observed after IMD treatment. Both hADM22-52 and hCGRP8-37 partially inhibited IMD actions. hIMD17-47 completely blocked the relaxation effect of IMD on both the contraction amplitude (A) and frequency (B). n=6 for all treatments. Data are presented as mean±SEM. *P<0.01 vs control or blocker alone, ** P<0.01 vs IMD, #P<0.01 vs hADM22-52+IMD or hCGRP8-37+IMD.