CCL2
|
Increase: epithelial HEnC
|
No change; mixed endometrial cells1[45]
|
Regulation of angiogenic and immunotolerant environment [57, 58]
|
CXCL10
|
Increase; mixed HEnC
|
Increase; HEEC1[14]
|
Regulation of NK cell recruitment and angiogenesis [59, 60]
|
FGF2
|
Increase; stromal HEnC and mixed HEnC
|
Increase; HEEC1[14]
|
Regulates endometrial stromal cell proliferation and receptivity and embryo growth, attachment and trophoblast function [61, 62]
|
GMCSF
|
Increase; stromal HEnC and mixed HEnC
|
Increase; HEEC1[14]
|
Regulates endometrial stromal cells, leukocytes and capillaries along with embryotropic action [34, 53, 63]
|
IL-1b
|
Increase; stromal HEnC and mixed HEnC
|
Increase; intrauterine secretion2[39]
|
Mediates endometrial preparation for implantation [36, 58]
|
No change; mixed endometrial cells1[45]
|
Increase; endometrial secretion aspiration3[64]
|
IL-6
|
Increase; epithelial HEnC Decrease; stromal HEnC and mixed HEnC
|
Increase; intrauterine secretion2[39]
|
Regulates hCG secretion by trophoblast cells and endometrial development [36, 65, 66]
|
Increase; mixed endometrial cells1[67]
|
Decrease; HEEC1[7]
|
No change; HEEC1[14]
|
IL-12
|
Decrease (p40); epithelial HEnC
|
Endometrial secretion aspiration3[64]
|
Regulates NK cell function and mediates cell mediated immunity [68]
|
Increase (p70); mixed HEnC
|
IL-17
|
Increase; stromal HEnC
|
Increase; endometrial secretion aspiration3[64]
|
Potentially regulates chemokines and cytokines networks [69]
|
LIF
|
Increase; epithelial HEnC and mixed HEnC
|
No change; mixed endometrial cells1[67]
|
Supports endometrial receptivity and embryo development [36]
|
Increase; intrauterine secretion2[39]
|
Increase; HEEC1[7, 14]
|
MCSF
|
Decrease; epithelial HEnC and mixed HEnC
|
Decrease; intrauterine secretion2[39]
|
Paracrine regulation of stromal decidualization under progesterone dominance [70, 71]
|
MIF
|
Increase; epithelial HEnC and mixed HEnC
|
Increase; endomerial stromal cells1[9]
|
Paracrine regulation of immunomodulation, angiogenesis and growth [47, 72]
|
Decrease; stromal HEnC
|
TNF
|
Increase; mixed HEnC
|
Increase; mixed endometrial cells1[64]
|
Regulates balance of cytokine, chemokines and growth factors towards endometrial and embryo development [73, 74]
|
Increase; endometrial secretion aspiration3[39]
|
VEGF
|
Increase; stromal HEnC and mixed HEnC
|
Increase; intrauterine secretion2[39]
|
Regulates endometrial angiogenesis, permeability receptivity and embryo development [36, 75, 76]
|
Increase; HEEC1[7, 14, 77]
|
Increase; mixed endometrial cells1[78]
|
Increase; epithelial HEnC [25]
|