Profiles of cytokines secreted by isolated human endometrial cells under the influence of chorionic gonadotropin during the window of embryo implantation

Table 3 Summary of the major observations from the present study

(Description) Group	Concentration level of secretion (pg in μg protein) in basal condition	Name of cytokines showing differential¹secretion following administration of hCG
Group 1	≤1	CCL2 (+), TRAIL (+)
(Endometrial epithelial cells)	>1-10	CCL5 (+), CCL7 (-), CXCL12 (-), HGF (-), IL-12p40 (-), LIF (+), MCSF (-)
	>10-100	CCL4 (+), CXCL1 (-), MIF (+), SCGF (-)
	>100	IL-6 (+)
Group 2	≤1	IL1b (+), IL-16 (-), IL17 (+)
(Endometrial stromal cells)		CCL4 (+), FGF2 (+), IFNG (+), IL-6 (-), VEGF (+)
	>1-10	GMCSF (+), MIF (-)
	>10-100	None
	>100	None
Group 3	≤1	CCL3 (+), CXCL10 (+), IL-1b (+), IL-12p70 (+), IL-13 (+), IL-16 (-), LIF (+), PDGFbb (+), TNF (+), TRAIL (-)
(Endometrial mixed cells)	>1-10	CCL4 (+), CCL5 (+), CXCL9 (-), FGF2 (+), GMCSF (+), HGF (-), IFNG (+), MCSF (-)
	>10-100	GCSF (+), IL-8 (-), MIF (-), VEGF (+)
	>100	IL-6 (-)

(+), up-regulated. (-), down-regulated.
The cytokines, chemokines and growth factors which were regulated in cell culture group specific manner are shown in bold.
¹≥ 1.5-fold at P < 0.05.

ISSN: 1477-7827