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Table 2 Summary of top scored features retrieved from reports of enrichment analysis from input list of cytokines, chemokines and growth factors showing high basal secretion and/or differential secretion following administration of hCG

From: Profiles of cytokines secreted by isolated human endometrial cells under the influence of chorionic gonadotropin during the window of embryo implantation

Enrichment by Types of cell culture
Epithelial cells Stromal cells Mixed cells
(Active products) (Active products) (Active products)
[pValue; FDR] [pValue; FDR] [pValue; FDR]
Pathway maps Immune response Immune response Immune response
(CCL2, CCL4, CCL5, CCL7, XCL1, IL-6, IL-12, HGF) (CCL4, GMCSF, IFNG, IL-1b, IL-6, IL-17, MIF, VEGF) (CCL3, CCL4, CCL5, GCSF, GMCSF, HGF, IFNG, IL-1b, IL-6, MIF, TNF, VEGF)
[8.3E-08; 1.6E-05] [8.7E-08; 8.5E-06] [1.9E-09; 4.3E-07]
Macropinocytotic transport   Epithelial-mesenchymal transition
(HGF, MCSF)   (FGF2, HGF, IL-1b, TNF)
[1.2E-05; 5.7E-04]   [7.9E-05; 1.7E-05]
GO process Chemotaxis, leukocyte chemotaxis Chemotaxis, leukocyte chemotaxis Regulation of response to stimulus, signal transduction and cell communication
(CCL2, CCL3, CCL4, CCL5, CCL7, CXCL1, CXCL12, HGF, IL-6, MIF) (CCL4, IFNG, IL-1b, IL-6, IFNG, MIF, VEGF) (CCL4, CCL5, CXCL12, FGF2, GCSF, GMCSF, HGF, IL-13, LIF, MCSF, MIF, TNF, VEGF)
[9.9E-21; 7.9E-18] [2.0E-15; 3.2E-12] [1.8E-27; 3.7E-24]
  Regulation of response to stimulus Chemotaxis, leukocyte chemotaxis
  (CCL4, FGF2, IL-1b, IL-6, IL-17 VEGF) (CCL3, CCL4, CCL5, CXCL12, FGF2, HGF, IFNG, IL-1b, IL-6, MIF)
  [8.4E-14; 4.6E-11] [5.2E-22; 2.8E-19]
   Immune response
   (CCL3, CCL4, CCL5, CXCL9, CXCL10, GCSF, MCSF, IFNG, IL-1b, IL-6, IL-13, LIF, MCSF, MIF, TNF, VEGF)
   [4.0E-21; 1.2E-18]
Process networks Inflammation Immune response Inflammation
(CCL2, CCL3, CCL4, CCL5, CCL7, CXCL12, HGF, IL-6, IL-12, LIF, MCSF) (GMCSF, IL-1b, IL-6, IL-17, MIF) (CCL3, CCL5, GCSF, GMCSF, IFNG, IL-6, IL-13, LIF, MCSF, TNF)
[2.9E-09; 2.4E-07] [4.9E-09; 3.2E-07] [9.6E-13; 9.3E-11]
Chemotaxis Signal transduction  
(CCL2, CCL3, CCL4, CCL5, CCL7, CXCL1, CXCL12) (GMCSF, IFNG, IL-1b, VEGF)  
[5.7E-09; 2.4E-07] [9.9E-06; 3.1E-04]  
Chemotaxis Signal transduction Proliferation
(CCL2, CCL3, CCL4, CCL5, CCL7, CXCL1, CXCL12) (GMCSF, IFNG, IL-1b, VEGF) (CXCL12, FGF2, GCSF, GMCSF, HGF, LIF, VEGF)
[5.7E-09; 2.4E-07] [9.9E-06; 3.1E-04] [6.6E-12; 3.2E-10]
Immune response Inflammation Cell adhesion
(CXCL12, CCL2, CXCL1, IL-6, CCL7, MIF) (IL-1b, GMCSF, IFNG, CCL4, IL-6) (IL-1b, TNF, CCL3, VEGF, MIF, FGF2, CCL5, CCL4, CXCL12)
[1.5E-08; 2.4E-07] [1.5E-06; 3.1E-04] [3.3E-10; 1.1E-08]
Cell adhesion Anti-apoptosis Chemotaxis
(CCL2, CCL3, CCL4, CCL5, CCL7, CXCL1, CXCL12) (FGF2, GMCSF, IL-1b, IL-6, VEGF) (CCL3, CCL4, CCL5, CXC12, FGF2, IL-1b, MIF, VEGF)
[1.4E-08; 2.9E-06] [2.3E-05; 3.7E-04] [9.4E-10; 2.3E-08]
Proliferation Cell adhesion Anti-apoptosis
(CCL4, CCL5, CXCL12, HGF, IL-12) (FGF2, IL-1b, IL-6, VEGF) (CCL3, FGF2, GMCSF, HGF, IL-1b, IL-6, TNF, VEGF)
[2.4E-07; 4.1E-06] [1.4E-04; 1.0E-03] [5.8E-09; 9.4E-08]
   Immune response
   (GCSF, GMCSF, IL-1b, IL-6, MIF)
   [5.2E-08; 6.3E-07]
  1. FDR false discovery rate.