Table 2 Summary of top scored features retrieved from reports of enrichment analysis from input list of cytokines, chemokines and growth factors showing high basal secretion and/or differential secretion following administration of hCG

Immune response

Immune response

Immune response

(CCL2, CCL4, CCL5, CCL7, XCL1, IL-6, IL-12, HGF)

(CCL4, GMCSF, IFNG, IL-1b, IL-6, IL-17, MIF, VEGF)

(CCL3, CCL4, CCL5, GCSF, GMCSF, HGF, IFNG, IL-1b, IL-6, MIF, TNF, VEGF)

[8.3E-08; 1.6E-05]

[8.7E-08; 8.5E-06]

[1.9E-09; 4.3E-07]

Macropinocytotic transport

Epithelial-mesenchymal transition

(HGF, MCSF)

(FGF2, HGF, IL-1b, TNF)

[1.2E-05; 5.7E-04]

[7.9E-05; 1.7E-05]

Chemotaxis, leukocyte chemotaxis

Chemotaxis, leukocyte chemotaxis

Regulation of response to stimulus, signal transduction and cell communication

(CCL2, CCL3, CCL4, CCL5, CCL7, CXCL1, CXCL12, HGF, IL-6, MIF)

(CCL4, IFNG, IL-1b, IL-6, IFNG, MIF, VEGF)

(CCL4, CCL5, CXCL12, FGF2, GCSF, GMCSF, HGF, IL-13, LIF, MCSF, MIF, TNF, VEGF)

[9.9E-21; 7.9E-18]

[2.0E-15; 3.2E-12]

[1.8E-27; 3.7E-24]

Regulation of response to stimulus

Chemotaxis, leukocyte chemotaxis

(CCL4, FGF2, IL-1b, IL-6, IL-17 VEGF)

(CCL3, CCL4, CCL5, CXCL12, FGF2, HGF, IFNG, IL-1b, IL-6, MIF)

[8.4E-14; 4.6E-11]

[5.2E-22; 2.8E-19]

Immune response

(CCL3, CCL4, CCL5, CXCL9, CXCL10, GCSF, MCSF, IFNG, IL-1b, IL-6, IL-13, LIF, MCSF, MIF, TNF, VEGF)

[4.0E-21; 1.2E-18]

Inflammation

Immune response

Inflammation

(CCL2, CCL3, CCL4, CCL5, CCL7, CXCL12, HGF, IL-6, IL-12, LIF, MCSF)

(GMCSF, IL-1b, IL-6, IL-17, MIF)

(CCL3, CCL5, GCSF, GMCSF, IFNG, IL-6, IL-13, LIF, MCSF, TNF)

[2.9E-09; 2.4E-07]

[4.9E-09; 3.2E-07]

[9.6E-13; 9.3E-11]

Chemotaxis

Signal transduction

(CCL2, CCL3, CCL4, CCL5, CCL7, CXCL1, CXCL12)

(GMCSF, IFNG, IL-1b, VEGF)

[5.7E-09; 2.4E-07]

[9.9E-06; 3.1E-04]

Chemotaxis

Signal transduction

Proliferation

(CCL2, CCL3, CCL4, CCL5, CCL7, CXCL1, CXCL12)

(GMCSF, IFNG, IL-1b, VEGF)

(CXCL12, FGF2, GCSF, GMCSF, HGF, LIF, VEGF)

[5.7E-09; 2.4E-07]

[9.9E-06; 3.1E-04]

[6.6E-12; 3.2E-10]

Immune response

Inflammation

Cell adhesion

(CXCL12, CCL2, CXCL1, IL-6, CCL7, MIF)

(IL-1b, GMCSF, IFNG, CCL4, IL-6)

(IL-1b, TNF, CCL3, VEGF, MIF, FGF2, CCL5, CCL4, CXCL12)

[1.5E-08; 2.4E-07]

[1.5E-06; 3.1E-04]

[3.3E-10; 1.1E-08]

Cell adhesion

Anti-apoptosis

Chemotaxis

(CCL2, CCL3, CCL4, CCL5, CCL7, CXCL1, CXCL12)

(FGF2, GMCSF, IL-1b, IL-6, VEGF)

(CCL3, CCL4, CCL5, CXC12, FGF2, IL-1b, MIF, VEGF)

[1.4E-08; 2.9E-06]

[2.3E-05; 3.7E-04]

[9.4E-10; 2.3E-08]

Proliferation

Cell adhesion

Anti-apoptosis

(CCL4, CCL5, CXCL12, HGF, IL-12)

(FGF2, IL-1b, IL-6, VEGF)

(CCL3, FGF2, GMCSF, HGF, IL-1b, IL-6, TNF, VEGF)

[2.4E-07; 4.1E-06]

[1.4E-04; 1.0E-03]

[5.8E-09; 9.4E-08]

Immune response

(GCSF, GMCSF, IL-1b, IL-6, MIF)

[5.2E-08; 6.3E-07]