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Figure 4 | Reproductive Biology and Endocrinology

Figure 4

From: RUNX2, GPX3 and PTX3 gene expression profiling in cumulus cells are reflective oocyte/embryo competence and potentially reliable predictors of embryo developmental competence in PCOS patients

Figure 4

Transcripts levels of the target genes ( RUNX2 , PSAT1 , ADAMTS9 , CXCL1 , CXCL2 , CXCL3 , ITGB5 , GPX3 and PTX3 ) according to embryo quality in PCOS patients. mRNA expression of candidate genes (RUNX2, PSAT1, ADAMTS9, CXCL1, CXCL2, CXCL3, ITGB5, GPX3 and PTX3) in cumulus cells of PCOS patients, organized according to oocyte development capability after normal fertilization. The signal intensity for each gene is shown on the y-axis in arbitrary units determined by qRT-PCR analysis with GAPDH as an endogeneous reference. * indicates a significant difference in gene expression between CC categories (** p < 0.01, * p < 0.05). The results were presented as the means ± SEM. CCB+: cumulus cells from oocyte yielding blastocyst after 5–6 days of in vitro culture; CCB-: cumulus cells from oocyte that had not developed into blastocyst at Day 5/6.

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