Associations among serum pro- and anti-inflammatory cytokines, metabolic mediators, body condition, and uterine disease in postpartum dairy cows

Table 3 **Mean ± SEM* serum adipokine concentrations in cows with postpartum uterine inflammatory conditions in dairy cows**

Adipokine	n	Adiponectin (ng/mL)	Leptin (ng/mL)	TNF-a (ng/mL)	IL-1β (ng/mL)	IL-6 (ng/mL)	Insulin (ng/mL)	IGF-1 (ng/mL)
Metritis‡	5	479.8 ± 23.9^a	6.74 ± 0.34^a	2.21 ± 0.11^a	2.83 ± 0.14^a	3.23 ± 0.16^a	0.28 ± 0.01	135 ± 9.1
Clinical endometritis§	16	470 ± 23.5^a	6.42 ± 0.32^a	1.99 ± 0.10^ab	3.01 ± 0.15^a	3.34 ± 0.17^a	0.57 ±0.04	132 ± 9.3
Subclinical endometritis§	6	412 ± 20.6^b	4.64 ± 0.26^b	1.63 ± 0.08^b	3.42 ± 0.17^a	2.58 ± 0.13^b	0.42 ± 0.02	192 ± 12.1
Normal§	13	428 ± 21.4^b	3.91 ± 0.20^c	0.68 ± 0.03^c	1.51 ± 0.08^b	1.72 ± 0.09^c	0.45 ± 0.03	202 ± 16.3

‡ Mean ± SEM serum concentrations of adiponectin, leptin, TNF-α, IL-1β and IL-6 during Weeks 1 or 2 were used to determine the levels of adipokines in cows with metritis.
§Mean ± SEM serum concentrations of adiponectin, leptin, TNF-α, IL-1β and IL-6 during Week 5 were used to determine adipokine concentrations in cows with clinical endometritis, or subclinical endometritis, or normal cows.
^a-cWithin column, means without common superscript differ (P < 0.05).
*Controlling for body condition score categories [low (2 and 2.5) and high (3, 3.5 and 4)]; P < 0.05), weeks postpartum (P < 0.05), weeks postpartum by body condition score categories interaction (P < 0.05) and uterine inflammatory conditions by body condition score categories interaction (P < 0.05).