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Table 1 RUNX2 expression status in cumulus cells in correspondence with biochemical/ovarian stimulation factors and pregnancy achievement

From: Detection of RUNX2 gene expression in cumulus cells in women undergoing controlled ovarian stimulation

 

With expression (n = 13) Median ± SD

Without expression (n = 28) Median ± SD

p-value

Age (yrs)

32.0 ± 5.2

34.5 ± 4.0

0.877

BMI (kg/m 2 )

24.2 ± 6.6

22.7 ± 3.2

0.320

17.9-25.0

53.8%

71.4%

 

25.1-30.0

23.1%

21.4%

 

30.1-42.8

23.1%

7.1%

 

Infertility (yrs)

7.0 ± 4.0

4.0 ± 3.0

0.129

FSH (mIU/ml)

6.4 ± 2.6

6.4 ± 2.7

0.966

LH (mIU/ml)

4.6 ± 1.6

6.5 ± 2.7

0.016

PRL (ng/ml)

12.9 ± 9.5

15.9 ± 5.7

0.742

Stimulation dose (IU)

2600 ± 1446

2138 ± 898

0.165

Ovarian stimulation (days)

10.0 ± 1.0

10.0 ± 3.0

0.167

E2 levels at the day of hCG (pg/ml)

1874 ± 700

2957 ± 1543

0.013

Number of follicles

9.0 ± 1.0

10.0 ± 3.0

0.032

Number of oocytes

8.0 ± 1.0

10.0 ± 2.0

0.016

Number of fertilized oocytes

6.0 ± 2.0

7.0 ± 3.0

0.089

Oocyte maturity rate

0.75 ± 0.1

0.73 ± 0.1

0.817

Good quality embryos

0.69 (n = 9)

0.79 (n = 22)

0.465

Clinical pregnancy rate

0.12 (n = 1)

0.25 (n = 7)

0.210

  1. Distribution of age, biochemical and ovarian stimulation factors by RUNX2 expression in cumulus cells (Mann–Whitney test), as well as oocyte maturity and clinical pregnancy rates and good quality embryos corresponded to RUNX2 expression status. Statistical significance was defined at the level of 5% (p < 0.05).