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Table 1 RUNX2 expression status in cumulus cells in correspondence with biochemical/ovarian stimulation factors and pregnancy achievement

From: Detection of RUNX2 gene expression in cumulus cells in women undergoing controlled ovarian stimulation

  With expression (n = 13) Median ± SD Without expression (n = 28) Median ± SD p-value
Age (yrs) 32.0 ± 5.2 34.5 ± 4.0 0.877
BMI (kg/m 2 ) 24.2 ± 6.6 22.7 ± 3.2 0.320
17.9-25.0 53.8% 71.4%  
25.1-30.0 23.1% 21.4%  
30.1-42.8 23.1% 7.1%  
Infertility (yrs) 7.0 ± 4.0 4.0 ± 3.0 0.129
FSH (mIU/ml) 6.4 ± 2.6 6.4 ± 2.7 0.966
LH (mIU/ml) 4.6 ± 1.6 6.5 ± 2.7 0.016
PRL (ng/ml) 12.9 ± 9.5 15.9 ± 5.7 0.742
Stimulation dose (IU) 2600 ± 1446 2138 ± 898 0.165
Ovarian stimulation (days) 10.0 ± 1.0 10.0 ± 3.0 0.167
E2 levels at the day of hCG (pg/ml) 1874 ± 700 2957 ± 1543 0.013
Number of follicles 9.0 ± 1.0 10.0 ± 3.0 0.032
Number of oocytes 8.0 ± 1.0 10.0 ± 2.0 0.016
Number of fertilized oocytes 6.0 ± 2.0 7.0 ± 3.0 0.089
Oocyte maturity rate 0.75 ± 0.1 0.73 ± 0.1 0.817
Good quality embryos 0.69 (n = 9) 0.79 (n = 22) 0.465
Clinical pregnancy rate 0.12 (n = 1) 0.25 (n = 7) 0.210
  1. Distribution of age, biochemical and ovarian stimulation factors by RUNX2 expression in cumulus cells (Mann–Whitney test), as well as oocyte maturity and clinical pregnancy rates and good quality embryos corresponded to RUNX2 expression status. Statistical significance was defined at the level of 5% (p < 0.05).