Immunoregulation of follicular renewal, selection, POF, and menopause in vivo, vs. neo-oogenesis in vitro, POF and ovarian infertility treatment, and a clinical trial

Table 1 Working model of age-associated changes of ovary-committed bone marrow cells (OC-BMC) and hormonal signals (LH/hCG & E2) required for the initiation & resumption of oogenesis in human ovaries

Period of life	OC-BMC³	LH/hCG⁴	E2⁵	Oogenesis
First trimester - midpregnancy	yes	yes	yes	yes⁶
Last trimester - newborn	yes	no	yes	no ⁶
Postnatal - menarche	yes	no	no	no ⁷
The prime reproductive period ¹	yes	yes	yes	yes⁶
Premenopause ²	no	yes	yes	no ⁷
Postmenopause	no	yes	no	no ⁶

¹ From menarche till 38 +/-2 years of age.
² From 38+/-2 years till menopause.
³ MDC & T cells with commitment for stimulation of OSC to germ cell transformation.
⁴ Levels corresponding to the mid cycle LH peak, or more (hCG levels should be 10x more, since it has only a 10% affinity to the LH receptor compared to that of LH - see Ref. [124]).
⁵ Levels corresponding to the preovulatory E₂ peak, or more.
⁶ Confirmed.
⁷ Predicted.

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