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Figure 3 | Reproductive Biology and Endocrinology

Figure 3

From: Immunoregulation of follicular renewal, selection, POF, and menopause in vivo, vs. neo-oogenesis in vitro, POF and ovarian infertility treatment, and a clinical trial

Figure 3

The human fetal ovary (24 weeks). A) Sprouts of primitive granulosa cells (pgc) originating from OSC between adjacent mesenchymal cell cords. B) In the cortex the primitive granulosa cells associate with available oocytes (asterisk). C) Pericytes (white arrow) in mesenchymal cell cords release large quantities of Thy-1 (black arrows and arrowhead) among adjacent oocytes and primitive granulosa cells. D and E) Rete cord (rc) extensions underline OSC and secrete Thy-1 (arrowheads) collapsing into spikes (arrows). F and G) Secondary germ cells (black asterisks) originating by asymmetric division of OSC (white asterisks) show depletion of MHC heavy (F) and light chain (G). Staining as indicated in panels (see Figure 2 legend). G) beta 2 microglobulin (beta 2m) = MHC class I light chain. Asterisks indicate germ cells/oocytes. Abbreviations and arrows/arrowheads are explained in the text. Adapted in part from [100] with permission, © Humana Press.

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