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Figure 1 | Reproductive Biology and Endocrinology

Figure 1

From: Immunoregulation of follicular renewal, selection, POF, and menopause in vivo, vs. neo-oogenesis in vitro, POF and ovarian infertility treatment, and a clinical trial

Figure 1

The prime reproductive period doctrine. The incidence of trisomic fetuses (dotted line) exponentially increases after 38+2 years of age, i.e., after the termination of follicular renewal during the prime reproductive period (PRP). White line indicates fluctuation of primordial follicle numbers due to their cyclic atresia and renewal during the prime reproductive period. PF, primordial follicles; N, neonate; CH, childhood; M, menarche; AMA, advanced maternal age. Adapted from [94] with permission, © Informa Healthcare, London, UK.

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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