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Table 4 Time and dose-dependent effects of norepinephrine on pregnenolone production

From: Norepinephrine stimulates progesterone production in highly estrogenic bovine granulosa cells cultured under serum-free, chemically defined conditions

Time (h) Norepinephrine (M)
0 10-9 10-8 10-7
0 2.1 ± 1.2a 2.1 ± 1.2a 2.1 ± 1.2a 2.1 ± 1.2a
48 2.5 ± 1.6a 4.7 ± 1.4a 4.6 ± 1.3a 4.4 ± 1.2a
96 9.0 ± 1.6b 12.4 ± 1.4b 10.6 ± 1.4b 11.9 ± 1.4b
  1. Time and dose-dependent effects of norepinephrine on pregnenolone (ng/ml) production by highly estrogenic bovine granulosa cells cultivated with 0.1% PVA supplementation.
  2. a, b Means within a column with unlike superscripts differ (P < 0.05); values are least square means ± SEM (n=5 independent cultures).