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Table 2 Time and dose-dependent effects of norepinephrine on estradiol production

From: Norepinephrine stimulates progesterone production in highly estrogenic bovine granulosa cells cultured under serum-free, chemically defined conditions

Time (h)

Norepinephrine (M)

0

10-9

10-8

10-7

0

0.11 ± 0.4a

0.11 ± 0.4a

0.11 ± 0.4a

0.11 ± 0.4a

48

1.83 ± 0.4b

2.61 ± 0.42b

2.39 ± 0.4b

2.1 ± 0.38b

96

2.25 ± 0.5b

2.25 ± 0.42b

2.37 ± 0.4b

2.60 ± 0.4b

  1. Time and dose-dependent effects of norepinephrine on estradiol (ng/ml) production by highly estrogenic bovine granulosa cells cultivated with 0.1% PVA supplementation.
  2. a, b Means within a column with unlike superscripts differ (P < 0.05); values are least square means ± SEM (n=5 independent cultures).