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Table 1 Variables in the choice of COS protocol

From: Hormonal, functional and genetic biomarkers in controlled ovarian stimulation: tools for matching patients and protocols

Factors determining individual patients' response to ovarian stimulation Treatments used in ovarian stimulation protocols Protocol variations
Demographics and anthropometrics (e.g., age, BMI and race) Gonadotrophins:
r-FSH/LH/hCG
u-FSH/LH/hCG
GnRH agonist protocol (long, short and micro flare)
Genetic profile GnRH analogues:
Agonists
Antagonists
GnRH antagonist protocol (standard, mild and modified natural)
Health status Steroid hormones:
Progesterone
Oestradiol
Testosterone
DHEA
Agonist-antagonist protocol
Cause of subfertility Other treatments:
Aromatase inhibitors
Growth hormone
Clomiphene citrate
Natural cycles
Duration of subfertility   
Nutrition   
  1. BMI = body mass index; COS = controlled ovarian stimulation; DHEA = dehydroepiandrosterone; GnRH = gonadotrophin releasing hormone; hCG = human chronic gonadotrophin; LH = luteinising hormone; r-FSH = recombinant follicle-stimulating hormone; u-FSH = urinary follicle-stimulating hormone.