Preclinical pharmacological profile of nomegestrol acetate, a synthetic 19-nor-progesterone derivative

Table 3 Effect of hydrocortisone, NOMAC, and MPA on inflammatory response

Treatment	Dose (mg/kg)	Adrenal weight (mg)	Thymus weight (mg)	Granuloma weight (mg)
Vehicle	–	38.8 ± 1.4	607 ± 34	29.7 ± 1.5
Hydrocortisone	10	28.6 ± 1.1*	355 ± 42*	24.6 ± 1.4*
Hydrocortisone	80	25.0 ± 0.9*	139 ± 15*	22.0 ± 1.4*
NOMAC	2.5	36.2 ± 2.1	614 ± 43	23.3 ± 1.4*
	5	35.8 ± 1.7	586 ± 28	27.1 ± 2.5
	10	36.7 ± 1.0	576 ± 46	26.4 ± 1.6
MPA	2.5	32.4 ± 1.0*	636 ± 25	25.4 ± 1.7
	5	30.4 ± 1.5*	624 ± 42	25.8 ± 2.1
	10	24.2 ± 1.4*	512 ± 20*	24.6 ± 1.9*

Sample weights (mg) are shown as the mean ± standard error of the mean. ANOVA, analysis of variance; MPA, medroxyprogesterone acetate; NOMAC, nomegestrol acetate; * P<0.05 compared with the vehicle control group (ANOVA).

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