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Table 3 Effect of hydrocortisone, NOMAC, and MPA on inflammatory response

From: Preclinical pharmacological profile of nomegestrol acetate, a synthetic 19-nor-progesterone derivative

Treatment Dose (mg/kg) Adrenal weight (mg) Thymus weight (mg) Granuloma weight (mg)
Vehicle 38.8 ± 1.4 607 ± 34 29.7 ± 1.5
Hydrocortisone 10 28.6 ± 1.1* 355 ± 42* 24.6 ± 1.4*
80 25.0 ± 0.9* 139 ± 15* 22.0 ± 1.4*
NOMAC 2.5 36.2 ± 2.1 614 ± 43 23.3 ± 1.4*
5 35.8 ± 1.7 586 ± 28 27.1 ± 2.5
10 36.7 ± 1.0 576 ± 46 26.4 ± 1.6
MPA 2.5 32.4 ± 1.0* 636 ± 25 25.4 ± 1.7
5 30.4 ± 1.5* 624 ± 42 25.8 ± 2.1
10 24.2 ± 1.4* 512 ± 20* 24.6 ± 1.9*
  1. Sample weights (mg) are shown as the mean ± standard error of the mean. ANOVA, analysis of variance; MPA, medroxyprogesterone acetate; NOMAC, nomegestrol acetate; * P<0.05 compared with the vehicle control group (ANOVA).