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Table 2 Effect of progesterone, NOMAC, and MPA on the pituitary-adrenal axis in OVX rats

From: Preclinical pharmacological profile of nomegestrol acetate, a synthetic 19-nor-progesterone derivative

Treatment Dose (mg/rat/day) Rats (n) Adrenal weight (mg)
Control (No OVX) 16 46.59 ± 1.51*
Control (OVX) 28 53.32 ± 1.63
Progesterone (OVX) 10 10 39.98 ± 2.15*
NOMAC (OVX) 0.3 10 58.38 ± 3.53
1 19 60.28 ± 1.89*
3 9 59.43 ± 2.03*
MPA (OVX) 0.1 8 47.28 ± 2.66*
0.3 10 37.35 ± 1.77*
1 8 27.58 ± 1.15*
3 8 20.86 ± 1.14*
  1. Adrenal weight is shown as the mean ± the standard error of the mean.
  2. ANOVA, analysis of variance; MPA, medroxyprogesterone acetate; NOMAC, nomegestrol acetate; OVX, ovariectomized.
  3. * P<0.05 vs OVX control (ANOVA).