Figure 5
Mean urinary change in sodium/potassium (Δ[Na+]/[K+]) ratio in rats after oral administration of (A) spironolactone (SP), nomegestrol acetate (NOMAC), or nomegestrol (NOM); (B) SP, 17β-estradiol (E2), or NOMAC/E2; and (C) SP, drospirenone (DRSP), ethinyl estradiol (EE), or NOMAC/EE. t1, overnight urine; t3, urine collected during last time. Doses are in mg/kg. Results are shown as mean ± standard error of the mean. * P<0.05; ** P<0.01 indicates the results were statistically significant compared with placebo-treated animals (analysis of variance).