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Table 4 Estimates and description of top scored enriched categories of differentially regulated (eutopic-to-ectopic) co-expressed (DC) genes

From: Genome-wide expressions in autologous eutopic and ectopic endometrium of fertile women with endometriosis

Cluster identity (Total number of genes) [Number of genes with differential display: Up-regulated/Down-regulated]

Enriched category (p-value)

Gene symbols of major candidate genes (Vector of differential)

Cluster 1, K1 (3210) [208: 120/88]

Cell cycle (<0.01)

CCNB1, CDC45L, CENPF, NCAPD3, RAD51 (up);

 

CCND2, MYL9, ORC6L, TNPO1 (down)

IGF-1 receptor signalling (<0.01)

IGF2 (up), IGFBP5, CCND2 (down)

Cytoskeleton remodelling involving regulation of actin (<0.02)

MYH9, MYL9 (down)

O-glycan biosynthesis (<0.02)

GALNT1, GALNT7 (down)

Immune response(<0.02)

PGR (up), CCND2 (down)

G-protein signalling in TC21 regulation pathway (<0.02)

RRAS2 (up), RASGRP2 (down)

DNA damage (<0.03)

NBN, RAD51 (up), CCND2 (down)

Neurite outgrowth (<0.05)

MYH9, MYL9 (down)

Regulation of glucose and lipid metabolism (<0.05)

CYP51A1, FOXA (up), TNPO1 (down)

G-protein signalling in Rap1 regulation pathway (<0.05)

KRIT1 (up), RASGRP2 (down)

Progesterone action (<0.05)

CCNB1, PGR (up)

Signal transduction:

 

Erk interactions (<0.04)

DUSP4 (up)

AKT signaling (<0.05)

HSP90AA1 (up), CCDD2 (down)

Cluster 2, K2 (8194) [148: 0/148]

Immune response (0)

ACTG1, C3, C4B, C1QB, HLA-C, PTPN11/SHP2 (down)

Cell adhesion (0)

ACTG1, ITGB1, PTPN11/SHP2 (down)

Regulation of CFTR (0)

ACTG1, HSPA8, PSMB1, TSG101, UBC (down)

Signal transduction involving activin A signalling regulation (0)

BAMBI, H3F3A, UBC (down)

Slit-Robo signaling (<0.01)

ACTG1, ROBO3 (down)

Cytoskeletal remodelling (<0.01)

ACTG1, DSTN, RALGDS (down)

Glutathione metabolism (<0.01)

GSTM5, MGST3 (down)

Chemotaxis (<0.02)

ACTG1, GNG4, ITGB1 (down)

Apoptosis and survival (<0.02)

HSPA8, ACTG1 (down)

Glucose and lipid metabolism (<0.03)

APOE (down)

Neurite outgrowth (<0.03)

ACTG1, DSTN (down)

N-glycan biosynthesis (<0.04)

GALT, GANAB (down)

Cluster 3, K3 (6078) [102: 102/0]

Differentiation (0)

PRKCG (up)

Transcriptional regulation of amino acid metabolism (0)

MAX, PRKCG (up)

Androgen receptor nuclear signaling (<0.01)

NCOA2/GRIP1, WNT16 (up)

Neurophysiological process associated with PGE2-induced pain processing (<0.01)

GLRA3 (up)