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Table 3 Cross validated miRNAs and their selected target genes

From: Effect of luteal-phase support on endometrial microRNA expression following controlled ovarian stimulation

Symbol

GrpsIIa-I [ILL-FC]

GrpsIIc-IIa [ILL-FC]

Source

Symbol

Entrez gene name

Pathway (enrichment)

P Value

FDR

miR-223-3p (GUCAGUU)

1.389

1.111

1

VIM

vimentin

   

miR-223-3p (GUCAGUU)

1.389

1.111

1,2

RHOB

ras homolog family member B

   

miR-223-3p (GUCAGUU)

1.389

1.111

1

IRS1

insulin receptor substrate 1

   

miR-29b-3p (AGCACCA)

1.375

1.068

2,3

TUBB2A

tubulin, beta 2A class IIa

   

miR-29b-3p (AGCACCA)

1.375

1.068

1,2,3,4

SPARC

secreted protein, acidic, cysteine-rich (osteonectin)

extracellular matrix

1.29E-07

4.44E-06

miR-29b-3p (AGCACCA)

1.375

1.068

1,2,3

PIK3R1

phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

   

miR-29b-3p (AGCACCA)

1.375

1.068

2,3

MYBL2

v-myb myeloblastosis viral oncogene homolog (avian)-like 2

   

miR-29b-3p (AGCACCA)

1.375

1.068

1,2

COL5A3

collagen, type V, alpha 3

extracellular matrix

1.29E-07

4.44E-06

miR-29b-3p (AGCACCA)

1.375

1.068

32,3

COL5A2

collagen, type V, alpha 2

extracellular matrix

1.29E-07

4.44E-06

miR-29b-3p (AGCACCA)

1.375

1.068

1,2,4

COL4A1

collagen, type IV, alpha 1

extracellular matrix

1.29E-07

4.44E-06

miR-29b-3p (AGCACCA)

1.375

1.068

1,2,3,4

COL1A2

collagen, type I, alpha 2

extracellular matrix

1.29E-07

4.44E-06

miR-29b-3p (AGCACCA)

1.375

1.068

1,2,4

COL15A1

collagen, type XV, alpha 1

extracellular matrix

1.29E-07

4.44E-06

miR-9-5p (CUUUGGU)

2.104

−1.802

1

NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

   

miR-9-5p (CUUUGGU)

2.104

−1.802

1,2

FOXO1

forkhead box O1

   

miR-9-5p (CUUUGGU)

2.104

−1.802

1,2

FOXG1

forkhead box G1

positive regulation of cell proliferation

1.21E-08

1.67E-06

miR-9-5p (CUUUGGU)

2.104

−1.802

1,2,3

CDH1

cadherin 1, type 1, E-cadherin (epithelial)

   

miR-181a-5p (ACAUUCA)

1.376

−1.24

1,4

TRA@

T cell receptor alpha locus

   

miR-181a-5p (ACAUUCA)

1.376

−1.24

1,2

TIMP3

TIMP metallopeptidase inhibitor 3

   

miR-181a-5p (ACAUUCA)

1.376

−1.24

1,2

NOTCH4

notch 4

positive regulation of cell proliferation

1.21E-08

1.67E-06

miR-181a-5p (ACAUUCA)

1.376

−1.24

1,2

KRAS

v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

response to steroid hormone stimulus

6.24E-07

4.65E-05

miR-181a-5p (ACAUUCA)

1.376

−1.24

1,2,4

HOXA11

homeobox A11

   

miR-181a-5p (ACAUUCA)

1.376

−1.24

1,2

GATA6

GATA binding protein 6

   

miR-181a-5p (ACAUUCA)

1.376

−1.24

1,2

ESR1

estrogen receptor 1

response to steroid hormone stimulus

6.24E-07

4.65E-05

miR-181a-5p (ACAUUCA)

1.376

−1.24

1,2

CDKN1B

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

positive regulation of cell proliferation

1.21E-08

1.67E-06

miR-181a-5p (ACAUUCA)

1.376

−1.24

1,2,3,4

BCL2

B-cell CLL/lymphoma 2

response to steroid hormone stimulus

6.24E-07

4.65E-05

miR-196a-5p (AGGUAGU)

1.092

−1.342

1

IKBKB

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

   

miR-196a-5p (AGGUAGU)

1.092

−1.342

1,2,4

HOXC8

homeobox C8

   

miR-196a-5p (AGGUAGU)

1.092

−1.342

1,3

ANXA1

annexin A1

   

miR-99a-5p (ACCCGUA)

1.427

−1.48

1,2,3

MTOR

mechanistic target of rapamycin (serine/threonine kinase)

positive regulation of cell proliferation

1.21E-08

1.67E-06

miR-99a-5p (ACCCGUA)

1.427

−1.48

1,2,3

IGF1R

insulin-like growth factor 1 receptor

positive regulation of cell proliferation

1.21E-08

1.67E-06

miR-99a-5p (ACCCGUA)

1.427

−1.48

1,2,3

FGFR3

fibroblast growth factor receptor 3

positive regulation of cell proliferation

1.21E-08

1.67E-06

miR-128 (CACAGUG)

1.184

−1.345

1,2

TXNIP

thioredoxin interacting protein

response to steroid hormone stimulus

6.24E-07

4.65E-05

miR-128 (CACAGUG)

1.184

−1.345

2,3

TGFBR1

transforming growth factor, beta receptor 1

response to steroid hormone stimulus

6.24E-07

4.65E-05

miR-128 (CACAGUG)

1.184

−1.345

1,2

LDLR

low density lipoprotein receptor

response to steroid hormone stimulus

6.24E-07

4.65E-05

miR-128 (CACAGUG)

1.184

−1.345

1,2

E2F3

E2F transcription factor 3

positive regulation of cell proliferation

1.21E-08

1.67E-06

miR-128 (CACAGUG)

1.184

−1.345

1,2

ADORA2B

adenosine A2b receptor

   
  1. Ingenuity Pathway Analysis (Ingenuity® Systems, http://www.ingenuity.com). MiRNA Target Filter was applied using the strictest criteria (experimentally observed microRNA/gene targets only) filtered for genes previously identified for involvement in endocrine system disorders. Each of the seven miRNAs has multiple gene targets. Fold changes between groups as determined by Illumina miRNA array measurements are shown. Ingenuity target identifications are generated from multiple databases (Source). Pathway enrichments were calculated for the entire gene set using the NIAID DAVID functional enrichment tool [31, 32]. Genes that feature in both the cellular proliferation and the steroid hormone pathways are in bold (KRAS, BCL2, TGFBR1).
  2. [ILL-FC] = Illumina array-fold change; Source = 1.miRecords, 2.TargetScan Human, 3.Ingenuity Expert Findings, 4.TarBase; FDR = False Discover Rate.
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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