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Table 3 Cross validated miRNAs and their selected target genes

From: Effect of luteal-phase support on endometrial microRNA expression following controlled ovarian stimulation

Symbol GrpsIIa-I [ILL-FC] GrpsIIc-IIa [ILL-FC] Source Symbol Entrez gene name Pathway (enrichment) P Value FDR
miR-223-3p (GUCAGUU) 1.389 1.111 1 VIM vimentin    
miR-223-3p (GUCAGUU) 1.389 1.111 1,2 RHOB ras homolog family member B    
miR-223-3p (GUCAGUU) 1.389 1.111 1 IRS1 insulin receptor substrate 1    
miR-29b-3p (AGCACCA) 1.375 1.068 2,3 TUBB2A tubulin, beta 2A class IIa    
miR-29b-3p (AGCACCA) 1.375 1.068 1,2,3,4 SPARC secreted protein, acidic, cysteine-rich (osteonectin) extracellular matrix 1.29E-07 4.44E-06
miR-29b-3p (AGCACCA) 1.375 1.068 1,2,3 PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)    
miR-29b-3p (AGCACCA) 1.375 1.068 2,3 MYBL2 v-myb myeloblastosis viral oncogene homolog (avian)-like 2    
miR-29b-3p (AGCACCA) 1.375 1.068 1,2 COL5A3 collagen, type V, alpha 3 extracellular matrix 1.29E-07 4.44E-06
miR-29b-3p (AGCACCA) 1.375 1.068 32,3 COL5A2 collagen, type V, alpha 2 extracellular matrix 1.29E-07 4.44E-06
miR-29b-3p (AGCACCA) 1.375 1.068 1,2,4 COL4A1 collagen, type IV, alpha 1 extracellular matrix 1.29E-07 4.44E-06
miR-29b-3p (AGCACCA) 1.375 1.068 1,2,3,4 COL1A2 collagen, type I, alpha 2 extracellular matrix 1.29E-07 4.44E-06
miR-29b-3p (AGCACCA) 1.375 1.068 1,2,4 COL15A1 collagen, type XV, alpha 1 extracellular matrix 1.29E-07 4.44E-06
miR-9-5p (CUUUGGU) 2.104 −1.802 1 NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1    
miR-9-5p (CUUUGGU) 2.104 −1.802 1,2 FOXO1 forkhead box O1    
miR-9-5p (CUUUGGU) 2.104 −1.802 1,2 FOXG1 forkhead box G1 positive regulation of cell proliferation 1.21E-08 1.67E-06
miR-9-5p (CUUUGGU) 2.104 −1.802 1,2,3 CDH1 cadherin 1, type 1, E-cadherin (epithelial)    
miR-181a-5p (ACAUUCA) 1.376 −1.24 1,4 TRA@ T cell receptor alpha locus    
miR-181a-5p (ACAUUCA) 1.376 −1.24 1,2 TIMP3 TIMP metallopeptidase inhibitor 3    
miR-181a-5p (ACAUUCA) 1.376 −1.24 1,2 NOTCH4 notch 4 positive regulation of cell proliferation 1.21E-08 1.67E-06
miR-181a-5p (ACAUUCA) 1.376 −1.24 1,2 KRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog response to steroid hormone stimulus 6.24E-07 4.65E-05
miR-181a-5p (ACAUUCA) 1.376 −1.24 1,2,4 HOXA11 homeobox A11    
miR-181a-5p (ACAUUCA) 1.376 −1.24 1,2 GATA6 GATA binding protein 6    
miR-181a-5p (ACAUUCA) 1.376 −1.24 1,2 ESR1 estrogen receptor 1 response to steroid hormone stimulus 6.24E-07 4.65E-05
miR-181a-5p (ACAUUCA) 1.376 −1.24 1,2 CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) positive regulation of cell proliferation 1.21E-08 1.67E-06
miR-181a-5p (ACAUUCA) 1.376 −1.24 1,2,3,4 BCL2 B-cell CLL/lymphoma 2 response to steroid hormone stimulus 6.24E-07 4.65E-05
miR-196a-5p (AGGUAGU) 1.092 −1.342 1 IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta    
miR-196a-5p (AGGUAGU) 1.092 −1.342 1,2,4 HOXC8 homeobox C8    
miR-196a-5p (AGGUAGU) 1.092 −1.342 1,3 ANXA1 annexin A1    
miR-99a-5p (ACCCGUA) 1.427 −1.48 1,2,3 MTOR mechanistic target of rapamycin (serine/threonine kinase) positive regulation of cell proliferation 1.21E-08 1.67E-06
miR-99a-5p (ACCCGUA) 1.427 −1.48 1,2,3 IGF1R insulin-like growth factor 1 receptor positive regulation of cell proliferation 1.21E-08 1.67E-06
miR-99a-5p (ACCCGUA) 1.427 −1.48 1,2,3 FGFR3 fibroblast growth factor receptor 3 positive regulation of cell proliferation 1.21E-08 1.67E-06
miR-128 (CACAGUG) 1.184 −1.345 1,2 TXNIP thioredoxin interacting protein response to steroid hormone stimulus 6.24E-07 4.65E-05
miR-128 (CACAGUG) 1.184 −1.345 2,3 TGFBR1 transforming growth factor, beta receptor 1 response to steroid hormone stimulus 6.24E-07 4.65E-05
miR-128 (CACAGUG) 1.184 −1.345 1,2 LDLR low density lipoprotein receptor response to steroid hormone stimulus 6.24E-07 4.65E-05
miR-128 (CACAGUG) 1.184 −1.345 1,2 E2F3 E2F transcription factor 3 positive regulation of cell proliferation 1.21E-08 1.67E-06
miR-128 (CACAGUG) 1.184 −1.345 1,2 ADORA2B adenosine A2b receptor    
  1. Ingenuity Pathway Analysis (Ingenuity® Systems, http://www.ingenuity.com). MiRNA Target Filter was applied using the strictest criteria (experimentally observed microRNA/gene targets only) filtered for genes previously identified for involvement in endocrine system disorders. Each of the seven miRNAs has multiple gene targets. Fold changes between groups as determined by Illumina miRNA array measurements are shown. Ingenuity target identifications are generated from multiple databases (Source). Pathway enrichments were calculated for the entire gene set using the NIAID DAVID functional enrichment tool [31, 32]. Genes that feature in both the cellular proliferation and the steroid hormone pathways are in bold (KRAS, BCL2, TGFBR1).
  2. [ILL-FC] = Illumina array-fold change; Source = 1.miRecords, 2.TargetScan Human, 3.Ingenuity Expert Findings, 4.TarBase; FDR = False Discover Rate.