Figure 4From: PreImplantation Factor (PIF) promoting role in embryo implantation: increases endometrial Integrin-α2β3, amphiregulin and epiregulin while reducing betacellulin expression via MAPK in deciduasPIF does not directly affect MAPK activity. sPIF at different concentrations was added to purified enzymes in presence of enzyme substrate determining IC50 values. In all tested enzymes, sPIF did not interfere with the enzyme activity. a) MEK-1 b) ERK-1, c) ERK-2. d) p38-MAPK.Back to article page