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Figure 2 | Reproductive Biology and Endocrinology

Figure 2

From: PreImplantation Factor (PIF) promoting role in embryo implantation: increases endometrial Integrin-α2β3, amphiregulin and epiregulin while reducing betacellulin expression via MAPK in decidua

Figure 2

sPIF-induced promotion of pro-inflammatory genes is coupled with their secretion. HESC were cultured in presence with 100 nM sPIF for 24 hours. Triplicate cells were extracted and global mRNA was.analyzed (Affymetrix). Gene expression >3 fold was considered significant. Culture media of HESC was collected and pro-inflammatory ligands was analyzed using ELISA. a) sPIFpromotes mRNA expression of pro-inflammatory cytokines and adhesion molecules as compared to controls. (b) PIF promotes inflammatory cytokine and chemokine secretion by HESC, P < 0.05. The increase in gene expression was confirmed by increased secretion into the media.

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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