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Table 5 Frequencies of the stromal expression levels of GPER (nuclear and cytoplasmic) and the classical sex hormone receptors in different types of endometriosis

From: Expression of the G protein-coupled estrogen receptor (GPER) in endometriosis: a tissue microarray study

Receptor

Expression level

Ovarian Endometriosis

Peritoneal Endometriosis

Deep infiltrating Endometriosis

p-value

GPER nuc

High

27/27 (100%)

19/19 (100%)

28/28 (100%)

-

 

Low

0/27

0/19

0/28

 

ER-alpha

High

25/25 (100%)

18/18 (100%)

25/27 (92.6%)

0.2

 

Low

0/25

0/18

2/27 (7.4%)

 

ER-beta

High

11/27 (40.7%)

17/18 (94.4%)

7/26 (26.9%)

<0.001

 

Low

16/27 (59.3%)

1/18 (5.6%)

19/26 (73.1%)

 

PR

High

26/26 (100%)

18/19 (94.7%)

26/27 (96.3%)

0.3

 

Low

0/26

1/19 (5.3%)

1/27 (3.7%)

 
  1. GPER, G protein-coupled estrogen receptor (nuc nuclear staining); ER estrogen receptor; PR progesterone receptor. No cytoplasmic GPER expression was detected in the stroma of endometrium and endometriosis. P-Values were calculated by an exact 2-sided Pearson chi-square test; p ≤ 0.05 was considered as statistically significant and is reported in bold type.