Regulation of EP and FP mRNA by estradiol. The relative mRNA expression levels of EP1, EP2, EP3, EP4 and FP as measured by real-time PCR in uteri from ovariectomized rats treated with different doses of estradiol (E2) along with vehicle treated controls (OvxC). Box and whisker plots representing the median value with 50% of all data falling within the box. The whiskers extend to the 5th and 95th percentiles. Bars with asterisks are significantly (P < 0.05) different from OvxC.