|
Species
|
Placentation characteristics
|
Depth of Invasion
|
Molecule produce; # oligosaccharides (oligos); pI of dimer; circulating 1/2-life; relative biopotency
|
Brain mass(% body weight)
|
First appearance (million years ago)
|
|---|
|
Humans
|
Hemochorial
|
1/3 rd myometrium
|
CG; 8 oligos; pI 3.5; 1/2-life 36 h, 109X
|
2.4%
|
0.1
|
|
Advanced simian primates
|
Hemochorial
|
1/10th myometrium
|
CG; 6 oligos; pI 4.9; 1/2-life 6 h; 18X
|
0.74%
|
20
|
|
Early simian primates
|
Hemochorial
|
through decidua
|
CG; 5 oligos; pI 6.3; 1/2-life 2.4 h; 7.3X
|
0.17%
|
37
|
|
Prosimian primate
|
Epitheliochorial
|
non-implanting
|
LH; 3 oligos; pI 9.0; 1/2-life 0.33 h; 1X
|
0.07%
|
55
|
- The circulating 1/2-life of Advanced simian primate and Early simian primate CG was calculated using an equation that consider number of oligosaccharides on LH and human CG and the known circulating 1/2 life. C1/2 is circulating 1/2-life and number of oligosaccharides is #O, CR = 2.4#O x 1.9. Table summarizes published data (34-45)
