TY - JOUR AU - Morita, Yoshihiro AU - Wada-Hiraike, Osamu AU - Yano, Tetsu AU - Shirane, Akira AU - Hirano, Mana AU - Hiraike, Haruko AU - Koyama, Satoshi AU - Oishi, Hajime AU - Yoshino, Osamu AU - Miyamoto, Yuichiro AU - Sone, Kenbun AU - Oda, Katsutoshi AU - Nakagawa, Shunsuke AU - Tsutsui, Kazuyoshi AU - Taketani, Yuji PY - 2012 DA - 2012/02/23 TI - Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary JO - Reproductive Biology and Endocrinology SP - 14 VL - 10 IS - 1 AB - Resveratrol is a natural polyphenolic compound known for its beneficial effects on energy homeostasis, and it also has multiple properties, including anti-oxidant, anti-inflammatory, and anti-tumor activities. Recently, silent information regulator genes (Sirtuins) have been identified as targets of resveratrol. Sirtuin 1 (SIRT1), originally found as an NAD+-dependent histone deacetylase, is a principal modulator of pathways downstream of calorie restriction, and the activation of SIRT1 ameliorates glucose homeostasis and insulin sensitivity. To date, the presence and physiological role of SIRT1 in the ovary are not known. Here we found that SIRT1 was localized in granulosa cells of the human ovary. SN - 1477-7827 UR - https://doi.org/10.1186/1477-7827-10-14 DO - 10.1186/1477-7827-10-14 ID - Morita2012 ER -