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Table 1 Effect of BMP6 treatment on the number and embryo development of zygotes retrieved

From: Improvement of ovarian response and oocyte quality of aged female by administration of bone morphogenetic protein-6 in a mouse model

Mice age (weeks) BMP conc. (ng) Mice provided Zygotes flushed Zygotes fragmented (%) Zygotes flushed/mouse Zygotes cultured Blastocyst (%)
6-11 (young control) 0 (control) 7 118 12 (10.2%) 15.1 ± 4.7b 106 38 (35.8%)c
26-31 (aged control) 0 (control) 7 93 12 (12.9%) 11.6 ± 4.6 81 13 (16.0%)
0.01 8 105 16 (15.2%) 11.1 ± 5.5 89 25 (28.1%)c
0.1 11 171 9 (5.3%)a 14.7 ± 2.9b 162 48 (29.6%)c
1 10 134 13 (9.7%) 12.1 ± 4.5 121 14 (11.6%)
10 7 93 30 (32.3%) 9 ± 5.6 63 2 (3.2%)
  1. aP< .01 (vs. aged control, 0.01 ng, and 10 ng), bP< .05 (vs. aged control, 0.01 ng, and 10 ng), cP< .05 (vs. aged control, 1 ng and 10 ng).