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Table 1 Effect of BMP6 treatment on the number and embryo development of zygotes retrieved

From: Improvement of ovarian response and oocyte quality of aged female by administration of bone morphogenetic protein-6 in a mouse model

Mice age (weeks)

BMP conc. (ng)

Mice provided

Zygotes flushed

Zygotes fragmented (%)

Zygotes flushed/mouse

Zygotes cultured

Blastocyst (%)

6-11 (young control)

0 (control)

7

118

12 (10.2%)

15.1 ± 4.7b

106

38 (35.8%)c

26-31 (aged control)

0 (control)

7

93

12 (12.9%)

11.6 ± 4.6

81

13 (16.0%)

0.01

8

105

16 (15.2%)

11.1 ± 5.5

89

25 (28.1%)c

0.1

11

171

9 (5.3%)a

14.7 ± 2.9b

162

48 (29.6%)c

1

10

134

13 (9.7%)

12.1 ± 4.5

121

14 (11.6%)

10

7

93

30 (32.3%)

9 ± 5.6

63

2 (3.2%)

  1. aP< .01 (vs. aged control, 0.01 ng, and 10 ng), bP< .05 (vs. aged control, 0.01 ng, and 10 ng), cP< .05 (vs. aged control, 1 ng and 10 ng).