Bone morphogenetic protein-15 in follicle fluid combined with age may differentiate between successful and unsuccessful poor ovarian responders

Table 2 Comparison of the characteristics and IVF outcomes among poor responders subdivided by FF BMP-15 level and age

Parameter	Low BMP-15 (110)		High BMP-15 (97)		P value
	Group 1	Group 2	Group 3	Group 4
	(Age≤35, n=67)	(35<Age<40, n=43)	(Age≤35, n=56)	(35<Age<40, n=41)
No. of oocytes retrieved	3 (0–7)	3 (0–7)	3 (0–7)	3 (0–6)	0.300^a
ET cycle/started cycle	86.6%	74.4%	83.9%	85.4%	0.415^b
No. of embryos transferred	2 (0–3)	2 (0–3)	2 (0–3)	2 (0–3)	0.816^a
Implantation rate/embryo	20.4%	6.5%	28.9%	20.9%	0.011^c
					<0.001^d
					0.015^e
Chemical pregnancy rate/ET cycle	27.6%	15.6%	44.7%	37.1%	0.005^d
Chemical pregnancy rate/ET cycle	27.6%	15.6%	44.7%	37.1%	0.044^e
Clinical pregnancy rate/ET cycle	25.9%	12.5%	40.4%	34.3%	0.005^d
Clinical pregnancy rate/ET cycle	25.9%	12.5%	40.4%	34.3%	0.033^e
Live birth rate/ET cycle	20.7%	6.25%	38.3%	20%	0.054^c
Live birth rate/ET cycle	20.7%	6.25%	38.3%	20%	0.001^d
Miscarriage rate	20%	50%	5.3%	41.7%	0.035^d 0.012^f

^a Values presented as medians (ranges) and compared across four groups by the Kruskal-Wallis tests.
^b Comparison across four groups (likelihood ratio).
^c Group 1 vs. Group 2 (likelihood ratio).
^d Group 2 vs. Group 3 (likelihood ratio).
^e Group 2 vs. Group 4 (likelihood ratio).
^f Group 3 vs. Group 4 (likelihood ratio).

ISSN: 1477-7827