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Table 2 Comparison of the characteristics and IVF outcomes among poor responders subdivided by FF BMP-15 level and age

From: Bone morphogenetic protein-15 in follicle fluid combined with age may differentiate between successful and unsuccessful poor ovarian responders

Parameter Low BMP-15 (110) High BMP-15 (97) P value
Group 1 Group 2 Group 3 Group 4
(Age≤35, n=67) (35<Age<40, n=43) (Age≤35, n=56) (35<Age<40, n=41)
No. of oocytes retrieved 3 (0–7) 3 (0–7) 3 (0–7) 3 (0–6) 0.300a
ET cycle/started cycle 86.6% 74.4% 83.9% 85.4% 0.415b
No. of embryos transferred 2 (0–3) 2 (0–3) 2 (0–3) 2 (0–3) 0.816a
Implantation rate/embryo 20.4% 6.5% 28.9% 20.9% 0.011c
<0.001d
0.015e
Chemical pregnancy rate/ET cycle 27.6% 15.6% 44.7% 37.1% 0.005d
0.044e
Clinical pregnancy rate/ET cycle 25.9% 12.5% 40.4% 34.3% 0.005d
0.033e
Live birth rate/ET cycle 20.7% 6.25% 38.3% 20% 0.054c
0.001d
Miscarriage rate 20% 50% 5.3% 41.7% 0.035d 0.012f
  1. a Values presented as medians (ranges) and compared across four groups by the Kruskal-Wallis tests.
  2. b Comparison across four groups (likelihood ratio).
  3. c Group 1 vs. Group 2 (likelihood ratio).
  4. d Group 2 vs. Group 3 (likelihood ratio).
  5. e Group 2 vs. Group 4 (likelihood ratio).
  6. f Group 3 vs. Group 4 (likelihood ratio).