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Table 3 IVF-ICSI cycle outcome in the two study groups

From: Clomiphene citrate versus high doses of gonadotropins for in vitrofertilisation in women with compromised ovarian reserve: a randomised controlled non-inferiority trial

  Previous Poor response Day 3 serum FSH > 12 UI/ml
Clomiphene (n=120) High dose rFSH (n=118) p Clomiphene (n=25) High dose rFSH (n=28) p
Cancelled cycle 16 (3%) 18 (15%) 0.67 5 (20%) 3 (11%) 0.29
Number of oocytes retrieved a 1.4 ± 1.1 2.8 ± 2.4 0.001 2.2 ± 0.8 2.8 ± 1.2 0.23
Fertilisation rate b 88% (83/94) 69% (132/190) 0.001 50% (10/20) 67% (31/46) 0.27
Women performing embryo transfer 50 (42%) 61 (52%) 0.12 6 (24%) 18 (64%) 0.004
Number of embryos transferred c 1.5 ± 0.7 1.8 ± 0.7 0.08 1.3 ± 0.5 1.6 ± 0.6 0.33
PR per started cycle 7% (8/120) 7% (8/118) 0.97 0% (0/25) 4% (1/28) 0.53
PR per embryo transfer 16% (8/50) 13% (8/61) 0.44 0% (0/6) 6% (1/18) 0.75
Embryos implanted (implantation rate) 12% (9/76) 9% (10/107) 0.63 0% (0/8) 7% (2/29) 1.00
DR per started cycle 4% (5/120) 5% (6/118) 0.74 0% (0/25) 4% (1/28) 0.53
DR per embryo transfer 10% (5/50) 10% (6/61) 1.00 0% (0/6) 6% (1/18) 0.75
  1. Data are expressed as mean ± SD or number (percentage) or percentage (ratio).
  2. a Refers to women who underwent oocyte retrieval.
  3. b Refers to all oocytes used.
  4. c Refers to women performing embryo transfer.
  5. PR: Clinical pregnancy rate. DR: Delivery Rate.