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Table 3 IVF-ICSI cycle outcome in the two study groups

From: Clomiphene citrate versus high doses of gonadotropins for in vitrofertilisation in women with compromised ovarian reserve: a randomised controlled non-inferiority trial

 

Previous Poor response

Day 3 serum FSH > 12 UI/ml

Clomiphene (n=120)

High dose rFSH (n=118)

p

Clomiphene (n=25)

High dose rFSH (n=28)

p

Cancelled cycle

16 (3%)

18 (15%)

0.67

5 (20%)

3 (11%)

0.29

Number of oocytes retrieved a

1.4 ± 1.1

2.8 ± 2.4

0.001

2.2 ± 0.8

2.8 ± 1.2

0.23

Fertilisation rate b

88% (83/94)

69% (132/190)

0.001

50% (10/20)

67% (31/46)

0.27

Women performing embryo transfer

50 (42%)

61 (52%)

0.12

6 (24%)

18 (64%)

0.004

Number of embryos transferred c

1.5 ± 0.7

1.8 ± 0.7

0.08

1.3 ± 0.5

1.6 ± 0.6

0.33

PR per started cycle

7% (8/120)

7% (8/118)

0.97

0% (0/25)

4% (1/28)

0.53

PR per embryo transfer

16% (8/50)

13% (8/61)

0.44

0% (0/6)

6% (1/18)

0.75

Embryos implanted (implantation rate)

12% (9/76)

9% (10/107)

0.63

0% (0/8)

7% (2/29)

1.00

DR per started cycle

4% (5/120)

5% (6/118)

0.74

0% (0/25)

4% (1/28)

0.53

DR per embryo transfer

10% (5/50)

10% (6/61)

1.00

0% (0/6)

6% (1/18)

0.75

  1. Data are expressed as mean ± SD or number (percentage) or percentage (ratio).
  2. a Refers to women who underwent oocyte retrieval.
  3. b Refers to all oocytes used.
  4. c Refers to women performing embryo transfer.
  5. PR: Clinical pregnancy rate. DR: Delivery Rate.