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Table 2 IVF-ICSI cycle outcome in the two study groups

From: Clomiphene citrate versus high doses of gonadotropins for in vitrofertilisation in women with compromised ovarian reserve: a randomised controlled non-inferiority trial

Characteristics

Clomiphene (n=145)

High dose rFSH (n=146)

p

Cancelled cycles

21 (14%)

21 (14%)

1.00

Number of follicles > 15 mm a

1.7 ± 1.1

2.8 ± 1.9

<0.001

Total number of follicles > 10 mm a

2.5 ± 1.4

4.1 ± 2.6

<0.001

Number of oocytes retrieved a

1.1 ± 1.1

2.0 ± 1.8

<0.001

    0

52 (42%)

29 (23%)

 

    1-2

58 (47%)

57 (46%)

<0.001

    ≥ 3

14 (11%)

39 (31%)

 

Fertilisation rate b

75% (93/124)

70% (164/236)

0.33

Women performing Embryo Transfer

56 (39%)

79 (54%)

0.008

Number of embryos transferred c

1.5 ± 0.7

1.7 ± 0.7

0.06

    1

33 (59%)

33 (42%)

 

    2

18 (32%)

35 (44%)

0.14

    3

5 (9%)

11 (14%)

 

Number of pregnant women

8

9

 

    PR per started cycle

5% (8/145)

6% (9/146)

1.00

    PR per retrieval

6% (8/124)

7% (9/125)

1.00

    PR per embryo transfer

14% (8/56)

11% (9/79)

0.81

Embryos implanted (implantation rate)

11% (9/84)

9% (12/136)

0.64

Number of live birth deliveries

5

7

 

    DR per started cycle

3% (5/145)

5% (7/146)

0.77

    DR per retrieval

4% (5/124)

6% (7/125)

0.78

    DR per embryo transfer

9% (5/56)

9% (7/79)

1.00

  1. Data are expressed as mean ± SD or number (percentage) or median (interquartile range) or percentage (ratio).
  2. a Refers to women who underwent oocyte retrieval.
  3. b Refers to all oocytes used.
  4. c Refers to women performing embryo transfer.
  5. PR: Clinical pregnancy rate. DR: Delivery Rate.