Multiple roles of TNF super family members in corpus luteum function

Table 1 Ovarian TNF and TNF receptors (TNFR) in various animals¹⁾

Species	Sources	Stages of the estrous cycle²⁾						Method of detection	Ref.
		F	I	II	III	R	P
TNF
Cow	Follicular fluid	+						Bioactivity	[24]
	Theca cells	+						IHC	[25]
	Corpus luteum				+	+		MDS/RIA	[26]
	Corpus luteum	+	+	+	+	+		RT-PCR/ELISA	[27]
	Corpus luteum						+	RT-PCR	[28]
Pig	Corpus luteum		+	+	+	+	+	RT-PCR	[29]
	Macrophages/CL		+	+	+			IHC	[30]
	EC/CL			+	+		+	IHC/Western blot	[31]
Human	Follicular fluid	+						ELISA	[32]
	Granulosa cells	+						IHC	[33]
	Theca cells	+						In situ hybridization	[34]
	Corpus luteum		+	+	+	+		IHC	[35]
Sheep	EC/TC	+						IF-microscopy	[36]
	Corpus luteum					+		Bioactivity	[37]
Rat³⁾	Granulosa cells					+		IHC	[25]
Mouse³⁾	GC/TC/CL		+		+	+		IHC	[38]
TNFR	(RI or RII)
Cow	GC/TC	+						RRA/cells	[39]
	Corpus luteum (RI)		+	+	+	+		RT-PCR/RRA	[27]
	Corpus luteum						+	RRA	[28]
	EC/CL			+				RRA/cells	[40]
	EC/LLC/SLC (RI)		+	+	+	+		RT-PCR	[41]
Pig	Granulosa cells	+						IHC	[42]
	LLC/SLC				+			RRA/cells	[43]
	Corpus luteum		+	+	+	+	+	RRA	[44]
Rat³⁾	Ovarian cells (RI, RII)						+	RT-PCR/RRA	[45]

¹⁾Abbreviations; TC: theca cells, GC: granulose cells, EC: endothelial cells, LLC: large luteal cells, SLC: small luteal cells, IHC: immunohistochemistry, RRA: radioreceptor assay. ²⁾Each stage of the estrous cycle was classified as follows; follicular (F), early-CL (I), mid-CL (II), late-CL (III), regressing CL (R), and pregnancy (P). ³⁾Each stage of the estrous cycle was classified as follows; estrus (I), metestrus (II), diestrus (III), proestrus (R), and pregnancy or pseudopregnancy (P).

ISSN: 1477-7827